Searchable abstracts of presentations at key conferences in endocrinology

ea0073pep12.7 | Presented ePosters 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Systems biology approach identifies key genes and related-pathways for childhood obesity

Crispim Daisy , Pellenz Felipe , Assmann Tais

IntroductionEpidemiological studies have suggested that obesity during childhood increases the risk of developing metabolic comorbidities, such as type 2 diabetes, later in life. Childhood obesity is a complex disease whose molecular mechanisms are not completely elucidated. However, studies have demonstrated that approximately 65% of the variation associated with obesity is due to genetic factors. In this context, a system biology approach could contrib...

ea0063p914 | Diabetes, Obesity and Metabolism 3 | ECE2019

miRNAs-target genes, miRNA-lncRNA, and miRNA-small molecules interactions involved in metabolic diseases

Assmann Tais Silveira , Milagro Fermin I , Martinez J Alfredo

Context: Metabolic diseases affect millions of people in both developed and transition countries. In addition to genetic inheritance of risk alleles, emerging evidence has shown that these diseases are also linked to lifestyle and inherited epigenetic pattern interactions. The strong link between epigenetics and metabolism may offer attractive clinical applications to counteract and manage the escalating prevalence of metabolic diseases, such as obesity, type 2 diabetes mellit...

ea0063p909 | Diabetes, Obesity and Metabolism 3 | ECE2019

Circulating microRNAs expression profile in individuals with obesity compared to healthy controls

Assmann Tais Silveira , Milagro Fermin I , Cuervo Marta , Riezu-Boj Jose I , Martinez J Alfredo

Context: Obesity is a global epidemic and an independent risk factor for several metabolic disorders. Emerging evidence suggests a role for epigenetic factors, such as microRNAs (miRNAs), in the development of obesity. MiRNAs are small non-coding RNAs that regulate gene expression. Moreover, circulating miRNAs are potential noninvasive biomarkers because they are stable in body fluids and can be detected using validated techniques, such as quantitative PCR. However, the identi...

ea0049oc2.1 | Diabetes Prediction and Complications | ECE2017

microRNA expression profile in plasma from patients with type 1 diabetes: a case–control study and bioinformatics analysis

Assmann Tais Silveira , Recamonde-Mendoza Mariana , Punales Marcia , Tschiedel Balduino , Canani Luis Henrique , Crispim Daisy

Context: Since the exact cause of type 1 diabetes mellitus (T1DM) remains unclear, the detection of novel biomarkers is necessary to complement the information obtained from the presence of autoantibodies together with genetic and environmental risk factors. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate gene expression. Changes in their expression were described in several pathological conditions, including autoimmune diseases. Circul...

ea0049gp79 | Diabetes & complications 1 | ECE2017

The rs2292239 polymorphism in the ERBB3 gene is associated with risk for type 1 diabetes mellitus

Crispim Daisy , Dieter Cristine , Lemos Natalia , Assmann Tais , Duarte Guilherme , Dorfman Luiza , Bauer Andrea

Background and Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from the complex interaction among multiple genes, environmental factors and the immune system. Genome-wide association studies identified ERBB3 (Erb-b2 receptor tyrosine kinase 3) gene as a main susceptibility locus for T1DM. This gene encodes a member of the family of intracellular receptors of protein tyrosine kinases, which activates multiple signaling pathways including PI3K-Ak...

ea0049gp93 | Diabetes therapy & complications 1 | ECE2017

microRNA expression profile in plasma from patients with diabetic kidney disease

Assmann Tais Silveira , Punales Marcia , Tschiedel Balduino , Canani Luis Henrique , Bauer Andrea Carla , Crispim Daisy

Introduction: Diabetic kidney disease (DKD) is the major cause of end-stage renal disease; however, the pathogenesis of this disease is not fully understood. Currently available therapies are not totally efficacious in the treatment and prognosis of DKD, suggesting that further understanding of the molecular mechanisms underlying the pathogenesis of this disease is necessary to improve its management. Recently, research on microRNAs (miRNAs) has become a hotspot because of the...

ea0049ep411 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus

Crispim Daisy , Duarte Guilherme , Assmann Tais , Dieter Cristine , de Souza Bianca , Canani Luis

Background and Aims: The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta-cells as well as in the regulation of Insulin gene expression in adults. Accordingly, genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 diabetes mellitus (T1DM) and glucose metabolism traits. Therefore, the aim of this study was to investigate the association of the rs7020673 (G/C) and r...

ea0035p352 | Diabetes (epidemiology, pathophysiology) | ECE2014

The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for developing T1DM

Assmann Tais , Brondani Leticia , Bauer Andrea , Canani Luis Henrique , Crispim Daisy

Introduction: Viral pathogens seem to play a role in triggering the autoimmune destruction that leads to type 1 diabetes mellitus (T1DM) development. Toll-like receptor 3 (TLR3) has been shown to recognize double-stranded RNA, a molecular signature of most viruses. It is expressed at high levels in pancreatic beta-cells and immune cells, suggesting a role for it in the T1DM pathogenesis. Therefore, the aim of this study was investigate if TLR3 polymorphisms are associ...

ea0035p353 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association between Asp299Gly and Thr399Ile polymorphisms in TLR4 gene and type 2 diabetes mellitus: Case-control study and meta-analysis

Assmann Tais , Lemos Natalia , Brondani Leticia , Carlessi Rodrigo , Canani Luis Henrique , Crispim Daisy

Introduction: Polymorphisms in genes that encode proteins of the innate immune system, such as the toll-like receptor 4 (TLR4), could affect the immune response as well as the prevalence of type 2 diabetes mellitus (T2DM). Activated TLR4 induces expression of a spectrum of proinflammatory cytokines, which have been implicated in insulin resistance. Some studies have reported associations of the TLR4 Asp299Gly and Thr399Ile polymorphisms with T2DM. However, ot...

ea0035p402 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis

Souza Bianca , Brondani Leticia , Assmann Tais , Boucas Ana Paula , Bauer Andrea Carla , Canani Luis , Crispim Daisy

Introduction: Some studies have reported associations between five uncoupling protein (UCP) 1–3 polymorphisms and obesity. This paper describes a case–control study and a meta-analysis conducted to determine if the following polymorphisms are associated with obesity: −3826A/G (UCP1); −866G/A, Ala55Val and Ins/Del (UCP2) and −55C/T (UCP3).Methods: The case–control study enrolled 282 obese and 483...