ea0025p205 | Growth and development | SFEBES2011
Stevens Adam
, Tajbakhsh Shahin
, Whatmore Andrew
, Westwood Melissa
, Clayton Peter
Girls with Turner syndrome (TS) are treated with recombinant human growth hormone (rhGH) to improve their adult height but the gain is variable (020 cm). Current prediction models can account for only ~46% of the variability in the first year response to rhGH, thus genetic profiling has been suggested as a possible means of improving this prediction. The aim of this study was to explore mRNA expression profiles in an ex-vivo fibroblast model to characterise response to r...