Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.03.03 | Adrenal (2) | ECE2015

Radiofrequency bipolar ablation therapy for primary aldosteronism patients: investigator-initiated exploratory clinical trial

Takase Kei , Seiji Kazumasa , Morimoto Ryo , Iwakura Yoshizugu , Ono Yoshikiyo , Omata Kei , Kudo Masataka , Kinoshita Tomo , Satoh Fumitoshi , Ito Sadayoshi

Purpose: To evaluate safety and efficacy of percutaneous radiofrequency ablation therapy for unilateral aldosterone producing adrenal adenoma in normalising aldosterone secretion.Patients: Eight cases of aldosterone producing adrenal adenoma with following conditions: i) CT detectable adenoma without any risky organs on a puncture route. ii) Intervening adipose tissue between target adenoma and adjacent risky organs (pancreas or intestine). iii) Unilater...

ea0056gp26 | Adrenal clinical | ECE2018

Segmental adrenal venous sampling may give a key to solution about the debate of cosyntropin stimulation or not

Satoh Fumitoshi , Tezuka Yuta , Morimoto Ryo , Omata Kei , Ono Yoshikiyo , Igarashi Yasuhiro , Kudo Masataka , Takase Kei , Ito Sadayoshi

Background: Adrenal venous sampling (AVS) is critical to differentiate unilateral primary aldosteronism (PA) subtype. However, there are large discrepancies between institutions in the diagnostic criteria of AVS. Especially, the most major debate is in whether cosyntropin stimulation should be used for localization diagnosis or not. Segmental AVS (S-AVS) is a refinement of central AVS (C-AVS) in which samples are taken from the tributaries of the central adrenal veins allowing...

ea0035p50 | Adrenal cortex | ECE2014

The pathophysiology of aldosterone-producing adenomas associated with their tumor size: the smaller, the higher expression of CYP11B2

Ono Yoshikiyo , Nakamura Yasuhiro , Maekawa Takashi , Felizola Saulo J A , Morimoto Ryo , Iwakura Yoshitsugu , Kudo Masataka , Seiji Kazumasa , Takase Kei , Gomez-Sanchez Celso E , Ito Sadayoshi , Sasano Hironobu , Satoh Fumitoshi

The pathophysiology of aldosterone-producing adenomas (APA), especially those manifesting clinically overt hyperaldosteronism despite their small size, remains unknown. Therefore, we examined the correlation between tumor size and the status of intratumoral steroidogenic enzymes involved in aldosterone biosynthesis using immunohistochemistry. Forty patients with surgically proven APAs following adrenal venous sampling were retrospectively studied. The tumor area at the maximum...