Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep202 | Calcium and Bone | ECE2024

Romosozumab therapy after parathyroidectomy for osteoporosis caused by primary hyperaparathyroidism: two case reports

Takebe Saya , Seki Yasufumi , Yamashita Kaoru , Takano Noriyoshi , Bokuda Kananko , Watanabe Daisuke , morimoto Satoshi , Ichihara Atsuhiro

Background: Primary hyperparathyroidism (PHPT) reduces bone mineral density (BMD), leading to secondary osteoporosis. While parathyroidectomy has been reported to increase BMD, the efficacy of medical therapy for PHPT-induced osteoporosis after parathyroidectomy remains uncertain. Herein, we report two PHPT cases with osteoporosis, where romosozumab, an anti-sclerostin monoclonal antibody, increased BMDs after parathyroidectomy.Case 1: A 67-year-old woma...

ea0099p224 | Adrenal and Cardiovascular Endocrinology | ECE2024

Comparison of antihypertensive effects between eplerenone and esaxerenone, mineralocorticoid receptor antagonists, in patients with primary aldosteronism

Morimoto Satoshi , Takebe Saya , Oyake Kentaro , Kitayama Saori , Ikemoto Makiko , Inoue Yuko , Sano Hisashi , Hirata Kiyotaka , Takano Noriyoshi , Yamashita Kaoru , Seki Yasufumi , Bokuda Kanako , Watanabe Daisuke , Ichihara Atsuhiro

Objective: The efficacy of mineralocorticoid receptor (MR) antagonists has been demonstrated in MR-related hypertension, including primary aldosteronism (PA). Non-inferiority in 24-hour blood pressure reduction has been shown for esaxerenone 2.5 mg/day compared to eplerenone 50 mg/day in patients with essential hypertension. However, no trial has compared the antihypertensive effects of these drugs in patients with PA. This study aimed to investigate the effect of switching fr...