Endocrine Abstracts

Introduction: Currently, it is unclear whether plasma free or 24-hour urinary metanephrines are preferable for diagnosis of pheochromocytoma/paraganglioma (PPGL) in children.Objectives: To investigate whether measurements of plasma free or 24-hour urinary fractionated metanephrines is a reliable test for screening for PPGL in children.Methods: This retrospective study included data from 60 children with and 78 without PPGL. Data in...

Background: Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of adrenal gland that can cause life-threatening complications due to overproduction of catecholamines. Per EANM/SNMMI 2019 guidelines for radionuclide imaging of PHEO and paraganglioma, 18F-fluoro-L-dihydroxyphenylalanine (18F-FDOPA) is recommended as a positron emission tomography (PET) radiotracer of choice followed by 68Ga-DOTA(0)-Tyr(3)-octreot...

Background: The purpose of this prospective study was to evaluate and compare the detection rates of 18F-L-dihydroxyphenylalanine (18F-FDOPA), 68Ga-DOTATATE, 18F-FDG, and 18F-fluorodopamine (18F-FDA) PET or positron emission tomography/computed tomography (PET/CT), computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of VHL-related pheochromocytoma (PHEO).<p class="abstext...

Background: To evaluate and compare the diagnostic performance of 68Ga-DOTATATE PET/CT to 18F-FDG PET/CT, CT of neck, chest, abdomen and pelvis (CT), and MRI of cervical, thoracic, and lumbar spine (MRI spine), for the detection of spinal bone metastases in metastatic pheochromocytoma and/or paraganglioma (PPGL).Methods: Between 2014 and 2019, 41 consecutive metastatic PPGL patients (19 females; mean age, 43 years) underwent 68...