Searchable abstracts of presentations at key conferences in endocrinology

ea0032p723 | Nuclear receptors and signal transduction | ECE2013

5/6 Nephrectomy reduces muscle mitochondria in mice as to decrease exercise endurance associated with further exacerbation by dietary protein

Tamaki Masanori , Miyashita Kazutoshi , Wakino Shu , Mitsuishi Masanori , Hayashi Koichi , Itoh Hiroshi

Introduction: Chronic kidney disease impairs physical performance from an early stage of disease, and the impairment is a critical medical problem because lowered physical activity correlates with renal prognosis and mortality, and constitutes an independent cardiovascular risk for chronic kidney disease patients, with as high an impact as hypertension and diabetes. In this study, the time course and mechanism of muscle insufficiency in renal failure were investigated using 5/...