Searchable abstracts of presentations at key conferences in endocrinology

ea0041s27.3 | Why do we gain weight; homeostasis and rewards of ingestive behaviour | ECE2016

How hypothalamus senses and stimulates food intake

Horvath Tamas L

Emerging evidence indicates that the hypothalamus is a key regulator of the adaptation of the central nervous system (CNS) to the changing environment in support of survival, with subsets of hypothalamic neurons acting as upstream regulators of brain regions classically considered as master determinants of CNS function, such as the cortex and hippocampus. The regulatory role of the hypothalamus in cortical and hippocampal functions is mediated via classical neuronal pathways a...

ea0014s12.3 | Hypothalamic network controlling food intake | ECE2007

The picture of the hypothalamus is becoming clearer: new concept of cross-talk

Horvath Tamas , Gao Qian , Diano Sabrina

Significant advancements have been made in the last century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanism of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral and pharmacological techniques have begun to elucidate...

ea0037s7.2 | Novel mechanisms of central weight regulation | ECE2015

Regulation of hypothalamic development by maternal nutrition

Vogt Merly , Paeger Lars , Hess Simon , Steculorum Sophie , Neupert Susanne , Predel Reinhard , Kloppenburg Peter , Horvath Tamas , Bruning Jens

In light of the ever-increasing incidences of obesity and T2DM, development of novel therapeutic or preventative measures to combat these epidemics is of utmost importance. Identification of a causal relationship between an altered maternal metabolic homeostasis and an increased propensity for the unborn child to develop metabolic disorders throughout lifetime has shifted considerable amount of attention towards understanding the underlying cellular and molecular alterations. ...