Endocrine Abstracts

Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, orexin-1 receptor (OX1R) and OX2R, which activate multiple G-proteins. In many tissues, orexins activate MAPKs, however, the mechanism by which OX2R alone mediates MAPK activation is not understood. We studied the intracellular signaling mechanisms involved in OX2R-mediated ERK1/2 and p38 MAPK activation. In HEK-293 cells stably over-expressing recombi...