Searchable abstracts of presentations at key conferences in endocrinology

ea0086p28 | Bone and Calcium | SFEBES2022

Is finger prick blood collection using Mitra® volumetric absorptive microsampling (VAMS) device a viable alternative to venous for testosterone, cortisol, 25 hydroxyvitamin D and bone resorption marker β-CTX measurements?

Dunn Rachel F , Washbourne Christopher J , Greeves Julie , Fraser William D , Tang Jonathan C Y

Background: Volumetric absorbent microsampling (VAMS) provides a less intrusive alternative to venepuncture when collecting blood samples for diagnostic testing. A small, precisely determined amount of capillary blood from a single finger-prick is absorbed into a medium for storage, from which it can later be extracted and analysed. In this study, we developed methods to measure four commonly requested endocrine/bone biomarkers for finger-prick blood samples analysis, and inve...

ea0095p10 | Bone | BSPED2023

LC–MS/MS measurements of serum zoledronate in children and young people receiving treatment – findings from the Moving Towards Individualised BisphosphonatE Therapy (TIBET) study

Bartlett Tabitha , Tang Jonathan C Y , Dunn Rachel , Subramanian Sharan , Fraser William D , Webb Emma

Background: Zoledronate is a nitrogen-containing bisphosphonate (BP) recognised for its antiresorptive potency. The pharmacokinetic/pharmacodynamic of zoledronate remains unclear. Although adverse events from overuse of BP is rare, there have been reports of over-treatment resulting in pathophysiological consequences. The current administration regimen is not tailored to the individual’s therapeutic response to zoledronate. Quantifying post-dose serum con...

ea0095p11 | Bone | BSPED2023

Assessment of children’s bone health: Establishing paediatric reference (prefer study) values for 1,25 vitamin D

Farag Amrou , Tang Jonathan C Y , Dunn Rachel , Chipchase Allison , Fraser William D , Webb Emma

Background: The active form of vitamin D, 1,25(OH)2D, plays a key role in regulating calcium and phosphorus metabolism and bone homeostasis. In paediatrics, maintaining optimal 1,25(OH)2D levels is crucial for supporting musculoskeletal growth. The hormone also serves as a diagnostic indicator for multiple disorders such as vitamin-D dependent rickets. Current Literature lacks comprehensive reporting of age-specific reference ranges in pa...

ea0095p89 | Bone 2 | BSPED2023

Establishing reference interval values of fibroblast growth factor 23 in paediatrics population

Chu Andre O C , Piec Isabelle , Fraser William D , Dunn Rachel , Farag Amrou , Chipchase Allison , Tang Jonathan C Y , Webb Emma

Background: Fibroblast growth factor 23 (FGF23) is a key protein in bone homeostasis regulatingserumphosphateand calcitriol (1,25(OH)2D3) concentrations. Analytical performance and reference ranges of FGF23 assays differ by molecule assayed (intact or C-terminal FGF23) and manufacturer. We aim to establish reference interval values for both cFGF23 and iFGF23 in a paediatric population.Methods: Writt...