Endocrine Abstracts

Introduction: Formation of immunological tolerance to self antigens is an important mechanism that prevents the development of autoimmune diseases.Methods: With the help of molecular genetic and immunofluorescence techniques we investigated the effects of experimental gestational diabetes (EGD) on the level of mRNA expression of autoimmune regulator Aire and differentiation features of Foxp3+ cells in mesenteric lymph nodes in the offspring of...

Introduction: Mesenteric lymph nodes (MLN) is a major transition point for recirculating lymphocytes of GALT. Homing of lymphocytes in MLN is regulated with adressin MAdCAM-1, chemokine receptors CXCR4 and CCR7. Sphingosine-1-phosphate receptors S1PR1 activate T-cell exit from MLN.Methods: We use RT-PCR method for investigating of mRNA expression levels of genes MAdCAM-1, CXCR4, CCR7 and S1PR in MLN of the offspring of rats with experimental gestational ...