Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep831 | Adrenal cortex (to include Cushing's) | ECE2017

ACTH-independent subclinical Cushing’s syndrome in patient with acromegaly and adrenal incidentaloma

Kurowska Maria , Malicka Joanna , Tarach Jerzy

Introduction: It is well established that acromegaly is associated with increased risk of cancer. However, it is currently unclear whether patients with acromegaly are at increased risk of developing adrenal tumors and little is known about the association between acromegaly and adrenal adenomas. The simultaneous occurrence of preclinical Cushing’s syndrome in patients with acromegaly and adrenal adenoma is extremely rare, and to our knowledge, so far only 5 such cases ha...

ea0049ep850 | Clinical case reports - Pituitary/Adrenal | ECE2017

Temozolomide alone or in combination with bevacizumab and capecitabine in the treatment of atypical pituitary adenomas – own experience

Kurowska Maria , Malicka Joanna , Tarach Jerzy

Introduction: Atypical pituitary adenomas are tumors refractory to conventional therapy and characterized by a tendency to rapid progression and high recurrence rate. The aim of the study was to summarize our experience in treatment of atypical pituitary adenomas with temozolomide (TMZ).Material: 5 patients (3F;2M) aged 44–58 (mean 52.4±5.4) years treated in 2013–2016. We analyzed the results, tolerance and side effects of TMZ.<p class...

ea0037ep175 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrine disorders in women with Turner syndrome

Zwolak Agnieszka , Dabrowska Anna , Tarach Jerzy

Introduction: Turner syndrome (TS) is the most common chromosomal abnormality in women. It occurs in 1/2500 to 1/3000 live-born females and results from a total or partial absence of the X chromosome. The clinical manifestations are diverse and TS is accompanied by multiple medical problems.Methods: We analysed retrospectively six cases of women with TS aged 20–66 years, treated at Endocrinology Department between 2003 and 2014, to describe endocrin...

ea0037ep776 | Pituitary: clinical | ECE2015

High diversity of Cushing's disease in patients with corticotrophic macroadenoma

Kurowska Maria , Malicka Joanna , Tarach Jerzy S

Introduction: In 7–20% of cases, Cushing’s disease is due to ACTH-producing macroadenoma. Aim of the study was to present our observations concerning etiologic, clinical, and therapeutic diversity of Cushing’s disease in patients with macrocorticotropinomas.Material and methods: Retrospective analysis of medical records of nine patients (5F; 4M) hospitalized in 2002–2015.Results: Four of the patients (2F; 2M) we...

ea0037ep1079 | Thyroid (non-cancer) | ECE2015

Multiple disease associations in autoimmune polyglandular syndromes

Dabrowska Anna , Zwolak Agnieszka , Tarach Jerzy

Introduction: Autoimmune polyglandular syndromes (APS) are a heterogeneous group of disorders characterised by autoimmune activity against endocrine and non-endocrine organs. APS type depends on the combination of the diseases (APS1, APS2, and APS3).Methods: The study was conducted in 89 patients (70F and 19M) with APS aged mean 50.00±14.80 years, treated at Endocrinology Department between 2003 and 2015. We analysed clinical manifestations, results...

ea0037ep1101 | Endocrine tumours | ECE2015

Von Hippel–Lindau disease: report of two cases

Dabrowska Anna , Tarach Jerzy , Zwolak Agnieszka

Introduction: Von Hippel–Lindau (VHL) disease is a rare autosomal dominant syndrome (1/36 000 live births) with highly penetrance that predisposes to the development of benign and malignant, highly vascularised tumours in many organs.Case reports: Two women with VHL, without family history of VHL, were admitted to Department of Endocrinology for checkups. The diagnosis was made based on genetic tests.Patient A: A 53-year-old w...

ea0037ep1264 | Clinical Cases–Thyroid/Other | ECE2015

Severe hyponatremia in the course of autoimmune polyglandular syndrome type 2 of atypical clinical picture

Kurowska Maria , Malicka Joanna , Jerzy , Tarach Stanislaw

Introduction: Severe hyponatremia defined as the blood sodium concentration below 115 mmol/l is rarely recognised in the course of autoimmune polyglandular syndrome type 2 (APS t.2). The aim of the paper is to present the female patient with severe hyponatremia preceding the diagnosis of APS t.2 of atypical clinical picture.Case report: A 54-year-old woman with the diagnosis of psoriasis established 10 years earlier and treated for psoriatic arthritis fr...

ea0035p227 | Clinical case reports Pituitary/Adrenal | ECE2014

Meningitis coexisting with pituitary macroadenoma: report of two cases

Malicka Joanna , Kurowska Maria , Tarach Jerzy S

Background: Meningitis coexisting with pituitary macroadenoma is rarely observed. It occurs either as a primary meningitis (primary tumor manifestation), or as a secondary meningitis (after neurosurgery or reduction of the volume of the tumor which has destroyed the sellar floor or the skull base).Objective: Case reports of two patients with the concomitance of secondary meningitis and pituitary macroadenoma.Case 1: A 36-year-old m...

ea0035p283 | Clinical case reports Thyroid/Others | ECE2014

Primary hyperparathyroidism due to parathyroid carcinoma: case report

Zwolak Agnieszka , Dabrowska Anna , Tarach Jerzy

Introduction: About 1% of primary hyperparathyroidism is due to parathyroid carcinoma. The affected gland is often indistinguishable from atypical adenoma. The proper diagnosis is usually made when the disease recurs or metastases are present and then is connected with poor prognosis.Case report: A 49-year-old man, after resection of parathyroid adenoma (postoperatively with normalization PTH concentrations and hungry bone syndrome), with limbs’ fra...

ea0016p742 | Thyroid | ECE2008

Iodine metabolism and effect of 131I therapy in Graves’ disease

Kijek Jolanta , Tarach Jerzy S , Kurowska Maria

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...