Endocrine Abstracts

Background: G-Protein Coupled Receptors-120 (GPR120) and GPR40 are of interest as targets for treating diabetes and obesity due to their involvement in incretin secretion. This study investigated the mechanistic function of dual agonism on regulating the regeneration of beta cell mass, proliferation, and the insulin secretory response, using CRISPR/Cas9 gene knockout cells and intracellular-signalling analysis.Methods: Clonal pancreatic BRIN-BD11 cells a...

Background: Pregnancy induces pancreatic islet β-cell mass expansion, but the exact mechanisms responsible remain unclear. It is nevertheless believed that disturbances in the process contribute to the development of gestational diabetes. The current study investigates the impact of pregnancy and cafeteria diet on islet morphology, cellular proliferation/apoptosis as well as endocrine cell lineage plasticity. Methods: Non-pregnant and pregnant Ins<e...