Endocrine Abstracts

Introduction: Prolactinomas are thought to arise from the proliferation of a mutated pituitary stem cell which is subjected to the growth stimuli of several permissive factors, although the pathogenetic mechanisms underlying the tumorigenesis still remain unclear. The present study aimed to investigate the role of p16 (540C→G and 580C→T) and MDM2 (SNP309T→G) gene polymorphisms in tumorigenesis and characteristics of prolactinoma.Methods...

Introduction: Oxidative stress is one of the possible mechanisms involved in the pathogenesis of the obesity-related metabolic complication. In this study, we aimed to investigate effect of weight loss with bariatric surgery on IMA, high sensitive C-reactive protein (hs-CRP), serum total antioxidant status (TAS), total oxidant status (TOS) levels.Materials and methods: In this prospective study, plasma IMA, hs-CRP, TAS and TOS levels were measured before...

Introduction: Gastrointestinal tract is one of the most affected systems in hypothyroidism. The most plausible mechanism in the pathogenesis is the development of interstitial edema subsequent to accumulation of glycosaminoglycans. Despite decreased esophageal emptying, prolonged esophageal and gastric transit time has been indicated in previous reports, the mechanism of thyroid hormones activity on the gastrointestinal system is not yet fully understood. To our knowledge, thi...

PURPOSE: To report a case of Cushing’s syndome caused by ectopic ACTH secretion related to a thymic carcinoid presented with trombositopenia.CASE: years old male presented with fatigue, skin rash. At presentation, physical findings showed Cushingoid appearance, with moon face, hyperpigmentation, easy bruising and buffalo hump. His laboratory findings showed platelet: 90.000 (150.000–450.000), ACTH: 609 pg/ml (0–46 pg/ml), baseline cortisol...