Searchable abstracts of presentations at key conferences in endocrinology

ea0031oc2.2 | Steroids and thyroid | SFEBES2013

Abnormal cardiac bio-energetics in subclinical hypothyroidism; cardiac magnetic resonance spectroscopic study

Madathil Asgar , Hollingsworth Kieren , Razvi Salman , Blamire Andrew , Taylor Roy , Newton Julia , Weaver Jolanta

Background: It is well established that subclinical hypothyroidism (SCH) is associated with mild ventricular dysfunction and early cardiovascular disease (CVD), but it is unknown if there is an underlying defect in cardiac bio-energetic function.Objective: To quantify the cardiac phosphocreatine/ATP (PCr/ATP) ratio in SCH, compare with healthy controls (HC) and to measure the effect of 6 months of thyroxine treatment.Method: Cardia...

ea0025p352 | Thyroid | SFEBES2011

Variation in free T3 (fT3) within the reference range is associated with bone development in children, and mediated via alteration in body mass indices

Taylor Peter , Sayers Adrian , Iqbal Ahmed , Taylor Andrew , Dayan Colin , Tobias Jonathan

Objective: The hypothalamus–pituitary–thyroid axis profoundly influences skeletal development. Whilst the adverse effects of thyroid dysfunction on bone are well established; the effects of variation within the normal range is less clear.Design: In a subset of the Avon Longitudinal Study of Parents and Children we performed full thyroid function tests from stored samples taken at age 7. 668 children had thyroid hormone parameters within the ref...

ea0025oc1.6 | Young Endocrinologists prize session | SFEBES2011

Evidence for the existence and significance of an alternative pathway towards androgen synthesis during early human life

Reisch Nicole , Dhir Vivek , Berry Andrew , Taylor Angela , Krone Nils , Nogueira Edson , Shackleton Cedric , Hanley Neil , Arlt Wiebke

Congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency (ORD) results in disordered sex development (DSD) in individuals of both sexes. POR provides electrons to CYP17A1 thereby facilitating synthesis of the major androgen precursor dehydroepiandrosterone (DHEA). ORD disrupts this enzymatic step, resulting in deficient synthesis of 5α-dihydrotestosterone (DHT) via DHEA, readily explaining undervirilisation (46,XY DSD) in male ORD neonates. Female virili...

ea0034oc1.1 | Young Endocrinologists prize session | SFEBES2014

The Thr92Ala substitution in deiodonase-2 is associated with increased odds of a sub-optimal IQ score in children with low-normal thyroid function

Taylor Peter , Okosieme Onyebuchi , Sayers Adrian , Northstone Kate , Draman Mohd , Stevenson Kirsty , Woltersdorf Wolf , Taylor Andrew , Pearce Elizabeth , Panicker Vijay , Ludgate Marian , Gregory John , Lazarus John , Timpson Nicholas , Channon Sue , Dayan Colin

Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability – free thyroxine in t...