ea0058oc4.4 | Oral Communications 4 | BSPED2018
Chan Li
, Hussain Mashal
, Forfar Rachel
, Khurana Puneet
, Cook Jennifer
, Lewis Steve
, McIver Ed
, Jerman Jeff
, Taylor Debra
, Clark Adrian
The overproduction of ACTH, in conditions such as Congenital Adrenal Hyperplasia (CAH) leads to significant morbidity. Current treatment with glucocorticoids does not adequately suppress plasma ACTH, resulting in excess adrenal androgen production. At present, there is no effective medical treatment that would directly block ACTH action. Such a therapy, especially one that can be orally administered, would be of great clinical value allowing a block and replace tre...