Searchable abstracts of presentations at key conferences in endocrinology

ea0056p259 | Calcium & Vitamin D metabolism | ECE2018

Primary hyperparathyroidism: a rare cause of hypertension?

Lopes Ana , Palma Isabel , Teixeira Sofia , Cardoso Helena

Backgroud: Primary hyperparathyroidism is the most common cause of hypercalcemia, which is associated with an increased frequency of hypertension. However, there are no data on the prevalence of primary hyperparathyroidism in patients who present with hypertension.Clinical case: We present the case of a 40-year-old woman with a history of hypertension for ten years. In 2017 she was referred for evaluation of hypercalcemia. The patient denied any symptoms...

ea0081p573 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Total daily dose of insulin at the beginning of treatment with Continuous Subcutaneous Insulin Infusion system: which is the best formula?

Benido Silva Vania , Garrido Susana , Vilaverde Joana , Teixeira Sofia , Cardoso Maria Helena

Introduction: Several formulas are described to calculate the Insulin Dose to start insulin pump therapy. However, there are no data demonstrating their effectiveness in achieving good glycemic control.Aim: To assess the Total Daily Dose of Insulin (TDDI) at 3 months after beginning an insulin pump, and determine which formula most closely matches the TDDI required in cases where good glycemic control is achieved after that period....

ea0070aep486 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glycemic variability in type 1 diabetes

Santos Tiago , Inácio Isabel , Soares Bruno , Vilaverde Joana , Teixeira Sofia , Cardoso Helena

Introduction: Glycemic variability (GV) is emerging as a measure of glycemic control in type 1 diabetic patients (T1DM) given that it provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes and is associated with diabetic complications and mortality. However, little is known about the best way to address this problem in clinical practice.Aim: To characterize GV in T1DM patients followed in our center and to identify clinica...

ea0070ep235 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Flash glucose monitoring in type 1 diabetes: Real world data

Borges Duarte Diana , Santos Tiago , Fonseca Liliana , Teixeira Sofia , Vilaverde Joana , Cardoso Maria Helena

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

ea0026p535 | Bone/calcium/Vitamin D | ECE2011

Prevalence of metabolic bone disease in Wilson’s disease (WD) patients

Teixeira Sofia , Domingos Joana , Carvalho Rui , Miranda Helena Pessegueiro , Magalhaes Marina

Background: Skeletal changes including demineralization have been reported in WD. The exact mechanism originating these changes isn’t completely understood but some authors have proposed a link to vitamin D (VitD) metabolism.Aim: To investigate the prevalence of demineralization in a cohort of WD patients and correlate it with VitD status and severity of hepatic and neurological involvement.Methods: Thirty-five patients (17 ma...

ea0022p225 | Clinical case reports and clinical practice | ECE2010

Necrotizing fasciitis as a complication of subcutaneous injection of insulin in a diabetic patient: a case report

Teixeira Sofia , Silva Ana Maia , Giestas Anabela , Vaz Daniel , Amaral Claudia

Necrotizing fasciitis is a rare infection of the soft tissues with consequent necrosis of fascial planes and surrounding tissues. If misdiagnosed or not properly treated it can be fatal. It typically follows trauma and it have already been described after intramuscular or intravenous injection of insulin.The authors present a case of a 24-year-old man, with type 1 diabetes mellitus for more than ten years, admitted to the emergency room for diabetic keto...

ea0056p1112 | Thyroid (non-cancer) | ECE2018

Levothyroxine absorption test: a safe help for difficult cases

Lopes Ana , Teresa Pereira Maria , Lito Pedro , Freitas Claudia , Teixeira Sofia , Cardoso Helena

Levothyroxine (L-T4) is the mainstay of treatment of hypothyroidism. Marked elevation of thyrotropin (TSH) in patients on high replacement doses is rare and can result from malabsorption, drug interaction or poor compliance. The levothyroxine absorption test is required to distinguish these causes and has proved to be safe. This test measures the serum free thyroxine (FT4) response to 1 mg of oral L-T4 over 4–24 h.Clinical cases: Case no 1: A 28-yea...

ea0073aep254 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Characterization of glycemic profile and glucose-lowering treatment in hospitalized patients of a central hospital by main diagnosis and length of stay

Patrícia Rosinha , Teixeira Sofia , Cláudia Amaral , Cardoso Helena

IntroductionGlycemic control during hospitalization has an impact on the length of hospital stay (LOS) and infection rates. This knowledge has led to a growing concern with hyperglycemia and its repercussions.ObjectivesThis study aims to evaluate the glycemic profile and diabetes mellitus (DM) treatment paradigm of hospitalized patients in a central hospital by main diagnosis and LOS.Me...

ea0081ep375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Phenotypical variability in hepatocyte nuclear transcription factor 1 beta (HNF1β) gene mutation – A five case report

V de Assuncao Guilherme , Fonseca Liliana , Mendes Catarina , Teixeira Sofia , Joao Oliveira Maria , Dores Jorge , Borges Teresa , Cardoso Helena

Introduction: MODY 5 is a rare form of autosomal dominant monogenic diabetes with a broad phenotypical spectrum that occurs with pancreatic and extra-pancreatic clinical manifestations, such as: malformation and dysfunction of the pancreas, nephrourologic anomalies, impaired renal function, hepatopathy and neurocognitive defects. It is caused by a mutation of the gene encoding hepatocyte nuclear transcription factor 1 beta (HNF1β).Case 1: M...

ea0063p919 | Diabetes, Obesity and Metabolism 3 | ECE2019

Diabetes Eruditus: Characteristics of type 1 diabetes of long duration

Duarte Diana Borges , Amaral Claudia , Amado Ana , Teixeira Sofia , Carvalho Andre , Vilaverde Joana , Freitas Claudia , Palma Isabel , Dores Jorge , Carvalho Rui , Bacelar Conceicao , Ramos Helena , Cardoso Helena

Introduction and aim: Type 1 diabetes mellitus (T1DM) presents as a challenge for both health care providers and patients looking to avoid chronic complications and early mortality. Clinical features of patients with long duration T1DM are still poorly studied and debated. The aim of our work was to describe the clinical features of subjects with long duration T1DM.Methods: Cross-sectional study of patients with T1DM with more than 40 years of evolution ...