Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc15.6 | Oral Communications 15: Late Breaking | ECE2021

Genetic polymorphism (IP-10/CXCL10) and diabetes mellitus type 1

Pashkunova Sylvia , Daneva Teodora , Vassilev Dimitar , Kostadinov Nikolay , Tsonev Stefan , Vangelova Joana , Vitanova Detelina

IntroductionThe development of Diabetes mellitus type 1 (DMT1) is considered as an autoimmune pro-inflammatory process. Human enteroviruses are thought to be also a cause. These viruses influence beta cells and cause expression of immunological factors. The affected cells destroy the related beta cells. The aim of the work is to study the genetic polymorphisms in IP-10/CXCL10 and its receptors CXCR3 and TLR4 in order to predict expression of DMT1.<p ...

ea0014p269 | (1) | ECE2007

Characterization of the rat homologue of the human neuroendocrine marker secretagogin – new functional implications by in vitro studies

Gartner Wolfgang , Vila Greisa , Daneva Teodora , Koc-Saral Felic , Majdic Otto , Nabokih Anastasia , Luger Anton , Wagner Ludwig

Objective: Establishment of rodent in vitro cell systems for the extension of the functional data about the recently cloned neuroendocrine marker secretagogin.Methods: 1. DNA-cloning; 2. Antibody generation; 3. Immunoblotting and Immunohistochemistry; 4. Cell-transfection; 5. Luciferase Reporter Assays; 6. ELISA.Results: 1. We characterized the rat homologue of human secretagogin (rat secretagogin) and demonstrated the homol...