Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep753 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly: a rare disease with multiple, complex complications

Istrate Andra Cristiana , Leustean Letitia , Ungureanu Maria- Christina , Teodoriu Laura , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

ea0063p569 | Diabetes, Obesity and Metabolism 2 | ECE2019

Body composition (DXA) and hormonal picture in obese children

Teodoriu Laura , Trandafir Laura , Ambarus-Popovici Ioana , Ioan Bianca , Ungureanu Maria-Christina , Preda Cristina

Introduction: Obesity in children is rising worldwide with premature development which could involve greater risk of complications and comorbidities in adult life. Central adiposity is a well known feature of glucocorticoid excess and there are some speculations that cortisol biosynthesis is involved in pathogenesis of metabolic syndrome. However the circadian rhythm of cortisol axis or incrimination of cortisol excess in obese children is less known. Our aim is to investigate...

ea0070ep441 | Thyroid | ECE2020

Management difficulties in nodular goiter associated with hypopharynx infiltration – case report

Teodoriu Laura , Magdalena Boboc Andreea , Neagu Georgiana , Ioan Bianca , Rosu Andreea , Christina Ungureanu Maria , Preda Cristina

Introduction: The connection between the pharynx and thyroid is close, so in the situations of concomitance: thyroid nodules and pharynx infiltration is very difficult to establish the primary lesion. Extralaryngeal spread of laryngopharyngeal cancer to the thyroid gland can occur by three pathways: direct extension, lymphatic spread or hematogenous spread. Of these three mechanisms, direct extension is the main mechanism because of the close anatomical relationship of the thy...

ea0056p35 | Adrenal cortex (to include Cushing's) | ECE2018

A four months infant survival case of waterhouse–friderichsen syndrome

Teodoriu Laura , Teodor Danut , Ungureanu Maria-Christina , Leustean Letitia , Ioan Bianca , Preda Cristina

Introduction: The Waterhouse–Friderichsen syndrome is a fulminating infection, often leading to mortality in a matter of hours by producing acute adrenal insufficiency (adrenal hemorrhage) at a time when their response is crucial to address acute stress.Case report: We present the case of a 4 months boy with high fever 40 °C, vomiting, diarrhea, lethargy, maculopapular rash followed by petechiae and purpura. Biological tests revealed important ...

ea0073aep401 | Endocrine-Related Cancer | ECE2021

Association of gastric GIST and Cushing syndrome

Teodoriu Laura , Dimofte Gabriel , Velenciuc Natalia , Ioan Bianca , Leustean Letitia , Ungureanu Christina , Preda Cristina

Gastrointestinal stromal tumors (GIST) are in high risk of developing additional malignancies, hereditary and also nonhereditary kind. Genetic changes are involved in the formation of GIST, about 80% are associated with KIT gene mutation and 10% of cases are associated with PDGFRA gene. These two mutations are found in both familial and sporadic GIST. We report a 65 years old female patient with a history of surgery for gastric GIST (T2N0). During the follow-up, after 4 years,...

ea0073ep131 | Endocrine-Related Cancer | ECE2021

Endocrine monitoring after severe hypercalcemia due to primary hyperparathyroidism. In search of lost…MEN 2A?

Teodoriu Laura , Hogea Maximilian , Scripcariu Viorel , Ioan Bianca , Leustean Letitia , Ungureanu Christina , Stefanescu Cipriana , Preda Cristina

The association between primary hyperparathyroidism and pheochromocytoma is present in multiple endocrine neoplasia type 2A (MEN 2A) along with medullary carcinoma or it can be a simple simultaneousness. The presence of the genetic mutation is mandatory in order to have a positive diagnosis of MEN. We report the case of a female patient 63 years old admitted in our department for a large adrenal incidentaloma (10 cm) with no clinical signs of adrenal dysfunction. An adrenal bi...

ea0081ep86 | Adrenal and Cardiovascular Endocrinology | ECE2022

Head and neck paraganglioma: exploring the metastasizing potential. Case report

Teodoriu Laura , Boboc Andreea , Patrascu Ana-Maria , Bilha Stefana , Leustean Letitia , Ungureanu Maria-Christina , Stefanescu Cipriana , Preda Cristina

Introduction: Paragangliomas (PGLs) are tumors originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting.Case report: We present the case of a 60 years old male patient, which was admitte...

ea0070ep11 | Adrenal and Cardiovascular Endocrinology | ECE2020

A case of coexisting carotid body paraganglioma, adrenal incidentaloma and malignant peripheral nerve sheath tumor. Coincidence or something more?

Neagu Georgiana , Ungureanu Maria-Christina , Iftimie-Gavrilas Irina , Teodoriu Laura , Rosu Andreea , Chiriac Bianca , Protop Madalina , Chelaru Alina , Preda Cristina

Introduction: Paraganglioma (PGL) is a neuroendocrine tumor (NET) originating from the neural crest cells. Head and neck paraganglioma (HNPGL) often presents as an asymptomatic slow growing tumor and is rarely functional. Adrenal incidentaloma (AI) is defined as a silent adrenal mass detected on imaging performed for unrelated disorder. Malignant peripheral nerve sheath tumor (MPNST) is a variety of soft tissue sarcoma derived from cells of neural crest....

ea0056p95 | Clinical case reports - Pituitary/Adrenal | ECE2018

Pitfalls in differential diagnosis of adrenal masses

Popovici Ioana Alexandra Ambarus , Chelaru Alina , Teodoriu Laura , Balaceanu Raluca , Leustean Letitia , Roata Cristian Ene , Tesloianu Anda , Preda Cristina

Introduction: Primary adrenal insufficiency (PAI) is a potentially life – threatening condition. About 75–80% of cases of PAI are caused by autoimmune destruction, while TB accounts for 7–20% of cases; however, adrenal tuberculosis is still the primary cause of PAI in developing countries. Adrenal tuberculosis is difficult to diagnose because symptoms are non-specific. Moreover, if the patient had no prior contact with TB patients, no past history of pulmonary T...

ea0056p1164 | Thyroid cancer | ECE2018

The prevalence of concomitent non-medullary thyroid carcinoma and primary hyperparathyroidism

Teodoriu Laura , Balaceanu Raluca , Ungureanu Maria-Christina , Leustean Letitia , Grigorovici Alexandru , Danila Radu , Ciobanu Gabriela-Delia , Stefanescu Cipriana , Preda Cristina

Introduction: Synchronous medullary thyroid cancer and pHPT is common in MEN-2A (Sipple syndrome). In contrast, concomitant nonmedullary thyroid cancer and primary hyperparathyroidism (PHPT) is very rare even if the pathological relationship between parathyroid and thyroid diseases is common.Aim: Was to determine the prevalence of non-medullary thyroid carcinoma in patient who underwent neck exploration for PHPT.Patients and method...