Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep152 | Bone and Calcium | ECE2020

Renal complications in chronic hypoparathyroidism – a german single-center analysis in 169 patients

Gronemeyer Karen , Teresa Fuss Carmina , Hermes Franca , Plass Armin , Koschker Ann-Cathrin , Hahner Stefanie

Introduction: Although long-term complications such as nephrocalcinosis and renal insufficiency are well-known in chronic hypoparathyroidism (HPT), standardized investigations of their prevalence and causes are still lacking.Objective: To systematically investigate the prevalence of renal calcifications and dysfunction and their predictors in a well-characterized cohort of patients with HPT.Methods: Cross-sectional assessment of co...

ea0070aep154 | Bone and Calcium | ECE2020

Psychiatric Comorbidities in Chronic Hypoparathyroidism – a German Single-Center Analysis in 107 Patients

Teresa Fuss Carmina , Hermes Franca , Koschker Ann-Cathrin , Unterecker Stefan , Deckert Jürgen , Hahner Stefanie

Introduction: Reduction of quality of life in patients with chronic hypoparathyroidism (HPT) has been reported by several studies. Additionally, self-report data point to a higher prevalence of anxiety disorders in HPT compared to patients after thyroidectomy.Objectives: To characterize psychiatric diseases in a systematically reviewed cohort of patients with chronic HPT.Methods: We systematically assessed psychiatric comorbidities...

ea0081rc14.4 | Rapid Communications 14: Late Breaking | ECE2022

Sequential primary adrenocortical culture system for genetic transformation and adrenocortical tumorigenesis using CRISPR/Cas9-mediated genome editing

Teresa Fuss Carmina , Hartmann Oliver , Reissland Michaela , Pahor Nikolett , Landwehr Laura-Sophie , Fassnacht Martin , Diefenbacherc Markus E

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 per million per year. Prognosis of ACC is generally poor but variable and therapeutic approaches are scarce. While surgical resection presents the best option for definitive cure, mitotane remains the only approved drug for adjuvant therapy in ACC to date. Advancements regarding novel treatment strategies as well as fostered understanding of potential drivers of adrenocortical carcinogenesis ...

ea0070aep96 | Adrenal and Cardiovascular Endocrinology | ECE2020

Confirmatory testing of primary aldosteronism with saline infusion test and LC-MS/MS

Teresa Fuss Carmina , Brohm Katharina , Kurlbaum Max , Hannemann Anke , Kendl Sabine , Fassnacht Martin , Deutschbein Timo , Hahner Stefanie , Kroiss Matthias

Objective: The saline infusion test (SIT) is a standard confirmatory test for primary aldosteronism (PA) and based on impaired aldosterone suppression in PA compared to essential hypertension (EH). In the past, aldosterone was quantified using immunoassays (IA). Due to the more widespread use of liquid chromatography tandem mass spectrometry (LC-MS/MS) in clinical routine, we aimed at a method-specific aldosterone threshold for the diagnosis of PA during SIT and explored the d...

ea0070aep151 | Bone and Calcium | ECE2020

Cardiovascular status in chronic hypoparathyroidism – a single-center analysis in 133 patients compared to the general german population

Teresa Fuss Carmina , Gronemeyer Karen , Hermes Franca , Dörr Marcus , Koschker Ann-Cathrin , Nordbeck Peter , Hannemann Anke , Hahner Stefanie

Introduction: Even though it is well known that long-term complications, such as renal insufficiency and brain calcifications can occur in patients with hypoparathyroidism (HPT), the risk of cardiovascular diseases still remains unclear.Objective: To perform a systematic assessment of cardiovascular function in a well-characterized cohort of patients with HPT compared to population-based controls.Methods: 133 patients with chronic ...