Searchable abstracts of presentations at key conferences in endocrinology

ea0081p700 | Reproductive and Developmental Endocrinology | ECE2022

Fetal exposure to anti-müllerian hormone triggers a transgenerational epigenetic transmission of polycystic ovary syndrome (PCOS) defects in adulthood

Nour El Houda Mimouni , Paiva Isabel , Barbotin Anne-Laure , Ezzahra Timzoura Fatima , Plassard Damien , Le Gras Stephanie , Ternier Gaetan , Pigny Pascal , Catteau-Jonard Sophie , Simon Virginie , Prevot Vincent , Boutillier Anne-Laurence , Giacobini Paolo

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder affecting women in reproductive age. Women with PCOS exhibit 2-3x higher levels of circulating Anti-Müllerian Hormone (AMH) as compared to healthy women and it is unclear if the elevation of AMH is a bystander effect or is driving the condition. Moreover, PCOS has a strong heritable component, however the etiopathology of the disease and the mechanisms underlying its transmission remain t...

ea0090oc7.1 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Mills Edouard G , Swedrowska Magda , Delli Virginia , Chachlaki Konstantina , Sergio Mauro , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...