Searchable abstracts of presentations at key conferences in endocrinology

ea0036P82 | (1) | BSPED2014

An audit to assess the impact of increasing the borderline blood spot TSH cut-off on the detection of cases of congenital hypothyroidism (CHT) identified via newborn screening

Tetlow Lesley , Ehtisham Sarah , Hird Beverly , Manfredonia Claire , Nice Daniella , Scargill Jonathan , Steele Caroline

Background: The UK Newborn Screening Programme Centre Clinical Referral Standards and Guidelines for CHT (2013) define TSH cut-offs for screen positive (>20 mU/l) and borderline (>10 and <20 mU/l) results. In Manchester levels >8 and <20 mU/l are classified as borderline. This audit aims to assess whether adopting the national cut-off would result in babies with significant and permanent hypothyroid disease being missed.Patient popula...

ea0058p023 | Growth | BSPED2018

Optimising diagnostic performance of IGF-I and IGFBP-3 measurement: importance of reference range and cut-off value

Al-Hashmi Laila , Manfredonia Claire , Banerjee Indi , Tetlow Lesley , Murray Philip , Clayton Peter

Background: The diagnosis of growth hormone deficiency (GHD) is based on a combination of clinical suspicion supported by growth hormone stimulation testing. IGF-1 and IGFBP-3 are used as supportive markers. Reports over the last decade have examined the performance of IGF-I and IGFBP-3 in the diagnosis of GHD. It is important that each unit evaluates the utility of these markers in the assay used by their laboratory based on relevant normative data.Aim:...

ea0045oc5.5 | Oral Communications 5- Endocrine | BSPED2016

The performance of early childhood Human Chorionic Gonadotrophin (HCG) testing to investigate male undervirilisation

van Geffen Joshua , Chinoy Amish , Ivison Fiona , Tetlow Lesley , Banerjee Indi

Background: The 3 day human chorionic gonadotrophin (HCG) test is commonly performed to investigate male undervirilisation. However, the utility of routine HCG testing for male undervirilisation in early childhood and correlation with pubertal progress is unclear.Aims: To review performance of the 3 day HCG test for diagnosis and outcomes.Methods: Standard 3 day HCG test data were analysed in 130 boys of age <3 years with under...

ea0036oc4.1 | Oral Communications 4 | BSPED2014

Utility of basal LH in comparison to the GnRH test for identifying central precocious puberty in girls

Shepherd Elizabeth , Patel Leena , Banerjee Indi , Clayton Peter , Ehtisham Sarah , Ivison Fiona , Padidela Raja , Skae Mars , Tetlow Lesley

Background: Harrington et al.1 suggest that basal LH of ≥0.3 IU/l as measured by ICMA (Immulite 2500) has 100% specificity and 90.5% sensitivity in identifying progressive central precocious puberty (CPP).Aims: To examine the utility of basal LH measured with the DELFIA assay for identifying CPP in girls.Methods: All girls under age 9 years (median 7.3 years) investigated for precocious puberty with a GnRH...

ea0030oc4.1 | Oral Communications 4 | BSPED2012

Metformin in obese children and adolescents: the MOCA trial

Kendall Deborah , Amin Rakesh , Barrett Timothy , Dimitri Paul , Ivison Fiona , Kibirige Mohammed , Mathew Verghese , Matyka Krystyna , Govern Ann Mc , Stirling Heather , Tetlow Lesley , Vail Andy , Wales Jerry , Wright Neil , Clayton Peter , Hall Catherine

Background: Childhood obesity is increasingly associated with type 2 diabetes (T2D). Metformin reduces the risk for T2D in adult obese non-diabetic patients, but the evidence in obese children and young people (CYP) is inconclusive.Design: The metformin in obese children and adolescents (MOCA) trial was a prospective, multi-centre, randomized, double-blind, placebo-controlled trial of 1.5 g metformin daily in CYP with raised fasting or post-prandial insu...

ea0028oc3.1 | Obesity, thyroid and Addison's disease | SFEBES2012

Metformin in obese children and adolescents (MOCA) trial

Kendall Deborah , Amin Rakesh , Barrett Timothy , Dimitri Paul , Ivison Fiona , Kibirige Mohammed , Mathew Verghese , Matyka Krystyna , Mc Govern Ann , Tetlow Lesley , Vail Andy , Wales Jerry , Wright Neil , Clayton Peter , Hall Catherine

Background and objective: Childhood obesity is associated with reduced insulin sensitivity and increased risk for type 2 diabetes (T2D). The objective of the MOCA trial was to investigate the effect of metformin in severely obese children and adolescents.Design and Methods: In a six month multi-centre randomized, double-blind placebo-controlled trial metformin (1.5 g daily) or placebo was given to children and adolescents (8–18 years) with insulin r...