Searchable abstracts of presentations at key conferences in endocrinology

ea0019p377 | Thyroid | SFEBES2009

Management of maternal hypothyroidism in the joint antenatal endocrine clinic

Thanabalasingham G , Ma K , Allen K , Street P , Elsheikh M

Background: In the first trimester, the foetus is dependent on circulating maternal thyroid hormones for normal brain development. Maintenance of euthyroidism is important throughout pregnancy and maternal hypothyroidism is associated with adverse foetal outcomes.Aim: To audit the management of pregnancies complicated by hypothyroidism in a joint antenatal endocrine clinic in comparison with the UK guidelines from the British Thyroid Association (2006).<...

ea0011p439 | Endocrine tumours and neoplasia | ECE2006

Hyperprolactinaemia in a series of adults with craniopharyngiomas and Rathke’s cleft cysts: what are the upper limits?

Thanabalasingham G , Karavitaki N , Meston N , Turner HE , Wass JAH

Introduction: Disruption of the hypothalamic dopaminergic inhibitory control of prolactin (PRL) secretion results in hyperprolactinaemia. We have previously shown in a large series of patients with non-functioning pituitary macroadenomas that serum PRL virtually never exceeds 2000 mU/l in the absence of PRL elevating medications. Current data on the effect of other sellar/parasellar masses are limited.Objective: To investigate the range of PRL values at ...

ea0013p244 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Non-surgical cerebro-spinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiological and clinicopathological features

Suliman SGI , Gurlek A , Byrne J , Sullivan N , Thanabalasingham G , Cudlip S , Ansorge O , Wass JAH

Objective: Macroprolactinomas (MPRL) may result in spontaneous or dopamine-agonist-induced CSF rhinorrhoea. The incidence of, and mechanisms underlying this phenomenon are poorly understood. In this study, we aimed to determine the incidence of non-surgical (spontaneous and dopamine-agonist-induced) rhinorrhoea, and to identify biochemical, radiological and histopathological factors associated with this phenomenon.Methods: We retrospectively reviewed MPR...