Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp40 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Long-term administration of Empagliflozin may promote hepatic and renal lipid accumulation, and inflammation in the APOE knockout model

Tsara Anna , Nasiri-Ansari Narjes , Dimitriadis Georgios K , Theocharis Stamatis , Karapanagioti1 Angeliki , Danas Eougken , Papavassiliou Athanasios G , Randeva Harpal S , Kassi Eva

Introduction: Metabolic disorders characterized by insulin resistance/hyperinsulinemia, such as metabolic syndrome and T2DM, are associated with Non-Alcoholic Fatty Liver Disease (NAFLD). SGLT-2i reduce reabsorption of glucose from the kidneys thereby promoting glucosuria, while their beneficial effects on insulin resistance have been recently recognized. In this study, we aimed to investigate the effect of Empagliflozin, in de novo triglyceride synthesis and beta-oxi...