ea0029oc4.5 | Pituitary Basic | ICEECE2012
Theodoropoulou M.
, Tichomirowa M.
, Cerovac V.
, Monteserin J.
, Rubinfeld H.
, Stalla G.
IGF-I receptors (IGF-IR) and their aberrant signaling cascade contribute to the pathogenesis of several solid cancers. Pituitary adenomas express IGF-IR and present with overactivation of the IGF-IR pathway. The aim of the study was to identify the potential antiproliferative action of the small molecule IGF-IR inhibitor NVP-TAE226 on acromegalic (n=11) and nonfunctioning pituitary adenomas (NFPA; n=15) in primary cell culture. Changes in cell viability were dete...