Searchable abstracts of presentations at key conferences in endocrinology

ea0038p141 | Growth and development | SFEBES2015

Inter-correlations between placental genes regulating foetal glucocorticoid exposure and IGF2 in maternal severe obesity: a mechanism for higher birthweight?

Mina Theresia , Riley Simon , Norman Jane , Reynolds Rebecca

Background: Maternal obesity in pregnancy associates with higher birthweight. A key pathway is through placental regulation of hormones controlling foetal growth. As excess foetal glucocorticoid exposure associates with lower birthweight and since placental Insulin-like Growth Factor (IGF2) may be modulated by glucocorticoids, we hypothesised that the expression profiles of placental genes leading to reduced glucocorticoid exposure and increased IGF2 mRNA level correlate with ...

ea0037oc7.3 | Neuroendocrinology and pituitary-basic | ECE2015

Maternal distress associates with placental genes regulating foetal glucocorticoid exposure and IGF2: role of obesity and sex

Mina Theresia , Raikkonen Katri , Riley Simon , Norman Jane , Reynolds Rebecca

Introduction: Maternal distress, including poorer life satisfaction, increased anxiety and depression (A&D) symptoms, are worse in Severely Obese (SO) than lean pregnancy and may alter placental genes regulating foetal glucocorticoid exposure and placental growth. We hypothesised that the associations between increased maternal distress with changes in placental mRNA levels leading to a reduced placental barrier to maternal glucocorticoids, and altered placental IGF2, are ...

ea0035p683 | Growth hormone IGF axis basic | ECE2014

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Siemienowicz Katarzyna , Boswell Lyndsey , Carr David , Mina Theresia , Connolly Fiona , Rae Mick , Duncan Colin

Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hepatic IGF1. The aim of this study was to investigate the molecular pathophysiology of this increase. We studied 11-month-old female offspring whose mother had been treated with testosterone propionate (TP: 100 mg) in oil (n=8), or oil control (n=4) twice weekly from day 62 to 102 gestatio...