Endocrine Abstracts

A 42-year-old man undergoing ipilimumab therapy for stage IV metastatic melanoma presented after his third dose with vomiting, abdominal pain, hypotension, and pyrexia. He was treated as a presumed line sepsis. Four days prior to admission, thyroid function test showed T4 of 7.9 pmol/l and TSH 0.02 mU/l and he was treated with levothyroxine. A pituitary profile was carried out on admission and the results were as follows, cortisol was 24 nmol/l, testosterone <0....

We describe the presentation of a 65 years old lady with upper gastrointestinal bleed to Altnagelvin Area Hospital in April 2023, eventually diagnosed with Cushing’s syndrome due to ectopic ACTH secretion from a high grade neuroendocrine tumor. Acute presentation was preceded by three months of general decline, weight loss, poor appetite and a history of smoking 20 cigarettes per day for more than 20 years. On examination, she was cachectic and delirious with cutaneous no...