Searchable abstracts of presentations at key conferences in endocrinology

ea0094p171 | Adrenal and Cardiovascular | SFEBES2023

A clinical case demonstrating the challenges in diagnosing and managing Paraneoplastic Cushing’s Syndrome

Iqbal Zohaib , Ho Jan , Walker Leanne , White Ann , Monaghan Philip , Thirkettle Sally , Gulamhusein Aziz , Keevil Brian , Mansoor Wasat , Adam Safwaan

We present a case of a 62-year-old lady with a grade 3 well-differentiated metastatic gastric-neuroendocrine tumour complicated by symptoms of CS (weight-gain, bruising, proximal weakness) which developed over 4 weeks. She had progressive disease after exhausting all conventional anti-neoplastic therapeutic options. Screening tests revealed raised 24-h urinary free cortisol (3460 nmol/24h[<165]), post-overnight dexamethasone suppression serum cortisol (serF) 1200 nmol/l(&#...

ea0094cc5 | Section | SFEBES2023

A case of an ACTH-secreting phaeochromocytoma: Biochemical response to metyrapone suggests the presence of a glucocorticoid-driven positive feedback loop

Michaelidou Maria , Phillips Benjamin , Man Mung Sai , Al-Hayali Mohammed , Chen Lilian , Allcock Rebecca , Monaghan Phillip , Thirkettle Sally , Clarke Noel , Gulamhusein Aziz , Beards Sue , Hoong Ho Jan , Kaushal Kalpana , Howell Simon , Adam Safwaan

Phaeochromocytoma-driven Ectopic ACTH Syndrome (EAS) is rare. We report the case of a 31-year-old female, who presented with abdominal pain and vomiting. She had clinical features of severe Cushing’s syndrome (proximal myopathy, bruising, refractory hypertension and acute confusion). Admission investigations revealed hypokalaemia (2.1mmol/l [3.5-5.5mmol/l]) and a 4.5cm left adrenal lesion with a ’bulky’ right adrenal on CT abdomen. She was diagnosed with hyperte...