Searchable abstracts of presentations at key conferences in endocrinology

ea0052p08 | (1) | UKINETS2017

Audit of a new nurse-led non-medical prescribing (NMP) clinic for systemic anti-cancer agents (SACTs)

Davies Philippa , Quaglia Elizabeth , McSweeney Aisling , Caplin Martyn , Thirlwell Christina

The number of people diagnosed and living with cancer in the UK continues to rise and this also places increasing demands on specialist cancer care services (NHS England 2015). Neuroendocrine Tumours (NETs) incidence and prevalence increases alongside this demand (PHE 2016). NETs still remain a rare cancer with specialist needs and the clinical nurse specialist (CNS) team are ideally placed to support these patients. Oncology clinics are becoming increasingly pressured and the...

ea0060oc3 | (1) | UKINETS2018

PUnNETS (Prediction of Unknown Neuroendocrine Tumour Site) – a DNA methylation-based classifier

Berner Alison M , Pipinikas Christodoulos , Karpathakis Anna , Dibra Harpreet K , Moghul Ismail , Webster Amy , Luong Tu Vinh , Thirlwell Christina

Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...

ea0025s2.2 | Novel pathways and treatments in neuroendocrine tumours | SFEBES2011

Integrated genome-wide DNA methylation and mRNA expression analysis of pancreatic NETs

Thirlwell Christina , Schulz Laura , Eymard Marianne , Meyer Tim , Davidson Brian , Teschendorff Andrew , Jiao Yan , Luong Tu-Vinh , Caplin Martyn , Beck Stephan

Integration of genetics and epigenetics has emerged as a powerful approach to study cellular differentiation and tumourigenesis. The study of DNA methylation is of particular importance in cancer as causal involvement has been demonstrated and it is the most stable of all epigenetic modifications, making it a desirable marker for both early detection and treatment of tumours. Hypermethylation of CpG sites in gene promoter regions leads to decreased gene expression, if such a g...