Endocrine Abstracts

A 79-year-old lady presented with a 6 months history of confusion and slurred speech and was found to have recurrent spontaneous hypoglycaemia (plasma glucose 1.3, 1.8 and 2.6 mmol/l). Pituitary and adrenal function were normal, and raised insulin (102 pmol/l) and C-peptide (630 pmol/l) levels confirmed the diagnosis of insulinoma, which was identified as a solitary 2 cm mass in the head of pancreas. Treatment with diazoxide 100–150 mg tds led to normalisation of g...

A 43-year-old female presented to the endocrine clinic with a 6-month history of polyuria and polydipsia. Investigations revealed a raised prolactin and a water deprivation test confirmed cranial diabetes insipidus. Subsequent pituitary MRI showed a likely pituitary microadenoma which however on further radiology review was thought to represent a hypothalamic/stalk lesion measuring up to 5 mm. She was commenced on intranasal desmopressin and cabergoline initially. Repeat MRI 2...

A 23-year-old gentleman with a 9-month history of extreme tiredness, muscle aches and pains, weight gain, cold intolerance and constipation presented to hospital with severe lethargy and dizziness and vacant episodes of increasing frequency. Initial examination revealed him to have a pulse rate of around 66 beats per minute. He was haemodynamically stable. A resting ECG showed an elevated ST segment of more than 2 mm with descent to an upward convexity to an inverted T wave es...