Searchable abstracts of presentations at key conferences in endocrinology

ea0025p5 | Bone | SFEBES2011

Risk factors for femoral neck fracture in Indian postmenopausal women (BMD, Vitamin D study and Propensity for a fall)

Paul Thomas , Arulselvan Sivan , Thomas Nihal , Seshadri Mandalam , Jose Arun

Introduction: Hip fractures are the most serious osteoporotic fractures and difficult to prevent them without a precise knowledge of the causative factors. The risk factors, which precipitate hip fracture in elderly may vary according to the local customs and practices. Indian data on risk factors for hip fractures are scant. The present study was undertaken to assess the various risk factors leading to femoral neck fracture in postmenopausal women and also to define the thres...

ea0019p151 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Body composition in HIV infected South Indian men

Thomas Nihal , Asha HS , Paul Thomas , Seshadri Mandalam

Background and objective: Widespread use of highly active anti-retroviral therapy (HAART) has led to a decrease in morbidity and mortality with this infection. HAART is also associated with body fat redistribution, insulin resistance and dyslipidemia, well known risk factors for cardiovascular disease. The prevalence of fat redistribution in studies ranges from 11 to 83%. The objective of this study was to look at changes in body composition in HIV infected men and to determin...

ea0034p27 | Bone | SFEBES2014

The diagnosis of osteoporosis among South Indian male and female subjects with low impact hip fracture and comparison between Indian Council of Medical Research and Caucasian Bone Mineral Density Databases

Thomas Nihal , Shetty Sahana , Kapoor Nitin , Asha H S , Naik Dukhabandhu , Visalakshi P , Paul Thomas

Aims and objectives: This study was undertaken to look at the agreement between the hologic database (HD) based on NHANES bone mineral density (BMD) data in Caucasians and the ICMR database (ICMRD) published in 2010 in defining normal and subnormal BMD in subjects with or without hip fracture and to arrive at a BMD cut off which has a high sensitivity of predicting fracture.Materials and methods: A cross sectional study of 3098 subjects (men-341 and wome...

ea0034p135 | Clinical practice/governance and case reports | SFEBES2014

Next generation sequencing approach for molecular genetic diagnosis of familial partial lipodystrophy

Thomas Nihal , Asha H S , Chapla Aaron , Manika V , Shetty Shrinath

Background: Familial partial lipodystrophy type 2 (FPLD2) is an autosomal dominant inherited form of lipodystrophy due to mutation in the LMNA gene on chromosome 1q22. It is characterized by selective loss of subcutaneous adipose tissue from the limbs and trunk, with accumulation of fat in the neck and face, insulin resistance, diabetes mellitus and dyslipidemia.Objective: To study the clinical features and establish the molecular diagnosis of two subjec...

ea0034p270 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Does TCF7L2 polymorphisms increase the risk of gestational diabetes mellitus in South Indian population?

Thomas Nihal , Mahesh D M , Chapla Aaron , Paul Johan , Shwetha N , Christina Flory , Asha H S

Introduction: Genetic predisposition with environmental factors plays a significant role in the development of type 2 diabetes mellitus. Among the diabetogenic genes, the transcription factor 7-like 2 (TCF7L2), a member of the Wnt signalling pathway remains the strongest genetic determinant of type 2 diabetes risk in humans. Our aim was to investigate whether TCF7L2 variants that have previously been associated with type2 diabetes would also confer risk for gestational diabete...

ea0031p17 | Bone | SFEBES2013

Risperidone associated changes in prolactin and bone mineral density: a study from South India

Paul Thomas , Ravan Jayaprakash Russell , Thomas Naveen , Thomas Nihal , Samuel Prasanna , Braganza Deepa

Background: Risperidone is a widely used antipsychotic, known to cause secondary hyperprolactinaemia. Hyperprolactinaemia is associated with erectile dysfunction, amenorrhea and reduced bone mineral density (BMD). However, there is insufficient information about the extent, severity and association between these side effects, particularly among the south Indian population.Aim and objectives: To estimate the prevalence of erectile dysfunction and amenorrh...

ea0031p27 | Bone | SFEBES2013

The diagnosis of osteoporosis among subjects of Southern Indian origin above 50 years of age: the impact of the indian council of medical research vs caucasian bone mineral density reference standards

Paul Thomas , Mruthyunjaya Mahesh , Shyamasunder Asha , Naik Dukhabandu , Rajaratnam Simon , Thomas Nihal , Seshadri Mandalam

Introduction: In the year 2010, the Indian Council of Medical Research (ICMR) has published a normative data for mone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) scanning. However, its impact on the diagnosis of osteoporosis when compared to currently used Caucasian database has not been analysed.Objectives: To study the effect of the newly generated ICMR database (ICMRD) on the diagnosis of osteoporosis compared with the Hol...

ea0031p31 | Bone | SFEBES2013

AUDIT of patients referred for DXA scanning in a south Indian Tertiary care centre

Paul Thomas , Mruthyunjaya Mahesh , Shyamasunder Asha , Naik Dukhabandu , Rajaratnam Simon , Thomas Nihal

Introduction: Osteoporosis is a silent disease and fractures pose enormous medical and financial burden on ageing individuals. Also subjects of younger age are at risk for subnormal bone mineral density when they have systemic disorders like rheumatoid arthritis or on long-term medications like corticosteroids. Preventive measures can be initiated if osteoporosis is diagnosed and treated before any fracture occurs. Even after the first fracture has occurred, there are effectiv...

ea0031p240 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Glycaemic variability: does it make a difference in prediabetes?

Paul Thomas , Garg Dinesh , Shyamasunder Asha , Thomas Nihal , Jeyaraman Kanakamani , Devanithi Nithya , Prasanna Samuel

Introduction: Glycaemic variability has been proposed as a contributing factor for development of diabetes related complications. This concept originated from Epidemiology of Diabetes Interventions and Complications (EDIC) study, in which, although the HbA1C was similar in conventional and intensively treated groups, the incidence of retinopathy was higher in the conventional group. This was attributed to glycaemic variability. Studying glycaemic variability in prediabetes wou...

ea0028p16 | Bone | SFEBES2012

A study of vitamin D status and Bone Mineral Density in epileptic patients from South India

Koshy George , Paul Thomas , Asha H , Thomas Nihal , Aaron Sanjit , Thomas Maya , Alexander Mathew , Seshadri M

Introduction: There are many reports describing the association of alternations of bone and mineral metabolism in patients with epilepsy receiving long term anticonvulsant therapy. However, there are only a few Indian studies which have looked at this aspect. Objective: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long term anticonvulsant therapy with age and BMI matched healthy co...