Searchable abstracts of presentations at key conferences in endocrinology

ea0021p152 | Diabetes and metabolism | SFEBES2009

At high dietary fat levels, dietary fish–oil may enhance metabolic efficiency but may favour a reduction in the deposition of adipose tissue

Sleeth Michelle , Thompson Emily , Anastasovska Jelena , Bell Jimmy , Frost Gary

Background: Obesity is the excessive accumulation of adipose tissue to the extent that health may be impaired. Determination of the mechanisms governing adipose deposition and body weight regulation are now a scientific priority. High dietary fat intake is generally considered to be a factor in obesity’s multi-factorial aetiology and the metabolic syndrome. Yet not all dietary fats appear to be obese genic to the same degree.Objective: To study the ...

ea0025p272 | Reproduction | SFEBES2011

Is age of vaginal opening an indicator of leptin sensitivity in female Sprague Dawley rats?

Sleeth Michelle , Beale Kylie , Thompson Emily , Baxter Jordan , Bloom Stephen , Murphy Kevin

Leptin is an adipocyte-derived cytokine critical to the integration of energy homeostasis and reproduction which putatively acts as a metabolic gate for the onset of puberty. However, it is unknown whether the age of puberty reflects leptin levels or leptin sensitivity. If pubertal age reflects leptin sensitivity, it may also reflect susceptibility to diet-induced obesity.We hypothesised that age of pubertal onset reflects leptin sensitivity. We assessed...

ea0025p278 | Reproduction | SFEBES2011

Neuromedin B stimulates the hypothalamo-pituitary–gonadal axis in male rats

Boughton Charlotte , Patel Sejal , Amin Anjali , Thompson Emily , Ghatei Mohammad , Bloom Stephen , Murphy Kevin

Neuromedin B (NMB) is a highly conserved bombesin-related peptide found in mammals. The mammalian bombesin family of receptors consists of three closely related G protein coupled receptors, BB1, BB2 and BB3. The BB1 receptor subtype has the highest affinity for NMB. NMB mRNA is detected in the CNS and is expressed at relatively high levels in the rat hypothalamus, in particular the medial preoptic area and the arcuate nucleus.<p ...

ea0021p237 | Neuroendocrinology and behaviour | SFEBES2009

Profiling the metabolic clearance and enzymatic degradation of the gut hormone Peptide YY as a tool to design long-acting PYY3–36 analogues in treating obesity

Addison Melisande , Thompson Emily , Minnion James , Murphy Kevin , Ghourab Samar , Hostomska Klara , Ghatei Mohammad , Bloom Stephen

Peptide YY (PYY) is a satiety hormone that communicates nutritional status to the central nervous system. PYY is released postprandially from endocrine L-cells in proportion to calories consumed. It is processed to generate the principle bioactive form PYY3–36, which acts on Y2 receptors in feeding centres within the brainstem and hypothalamus to reduce appetite. Chronic intravenous infusion of PYY3–36 induces weight loss in rodents, and obese humans display low plas...

ea0013oc38 | British Thyroid Association Award | SFEBES2007

The novel thyroid hormone derivative 3-iodothyronamine increases food intake via the hypothalamic arcuate nucleus

White Nicholas , Dhillo Waljit , Bewick Gavin , Gardiner James , Scutt James , Thompson Emily , Kokkinos Alexander , Armstrong Alan , Ghatei Mohammad , Bloom Stephen

3-iodothyronamine (T1AM) is a novel, endogenous rapid acting biogenic amine, which is a potent agonist of the G-protein coupled trace amine-associated receptor 1, TAAR1. It has been suggested that endogenous T1AM could be generated by enzymatic deiodonation and decarboxylation of T4. The presence of T1AM in rat brain and the distribution of the TAAR1 receptor in the hypothalamus suggest that T1AM may affect food intake and regulate e...

ea0013oc17 | Novartis Clinical Endocrinology Award | SFEBES2007

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.

Chaudhri Owais , Dhillo Waljit , Thompson Emily , Murphy Kevin , Salem Victoria , Patterson Michael , Donaldson Mandy , Amber Vian , Ramachandran Radha , Nijher Gurjinder , Kokkinos Alexander , Ghatei Mohammad , Bloom Steve

Kisspeptin, the endogenous ligand of the GPR54 receptor, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates and human males. The effects of kisspeptin administration to human females are not known.Aim: To investigate the effects of kisspeptin on luteinising hormone (LH) release during the menstrual cycle in fema...