Searchable abstracts of presentations at key conferences in endocrinology

ea0012oc20 | Pituitary, ovary and steroids | SFE2006

Novel activation of MAPK family proteins in pituitary GH3 somatotrophs and alphaT3-1 gonadotrophs by C-type natriuretic peptide (CNP)

Jonas KC , Thompson IA , Chand AN , Fowkes RC

In target tissues, CNP acts via the cell surface guanylyl cyclase B (GC-B) receptor to stimulate cGMP accumulation. Transgenic mice studies deleting either CNP or the GC-B receptor suggest a role for CNP in regulating bone formation and pituitary growth hormone secretion. Our previous studies have implicated a role for CNP in inhibiting calcium transients in alphaT3-1 pituitary gonadotroph cells; however the biological consequence of cGMP accumulation remains unclear. Therefor...

ea0011oc3 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006

Activation of cAMP (cAMP) binding protein (CREB) by gonadotrophin-releasing hormone (GnRH) requires calcium influx and PKC activity in gonadotroph cell lines

Jonas KC , Thompson IA , Burrin JM , Fowkes RC

The ubiquitous transcription factor, CREB, is responsible for mediating gene transcription in many endocrine tissues. Recent studies reveal that the activation of several signalling pathways can lead to the phosphorylation of CREB at Ser133, including PKC, MAPKs, CaMKs, and PI3K. In the pituitary gonadotroph, there are consensus cAMP response elements (CREs) in several of the gonadotrophin subunit promoters as well as in the GnRH receptor promoter. We have previously shown tha...