Searchable abstracts of presentations at key conferences in endocrinology

ea0035p306 | Clinical case reports Thyroid/Others | ECE2014

Long-term use of tolvaptan in hyponatraemia due to SIADH in elderly

Pothina Narayana Prasad , Sathyapalan Thozhukat

Background: Hyponatraemia is the most common electrolyte disorder seen in clinical practice. Even mild hyponatraemia can lead to gait disturbances and cognitive dysfunction in the elderly.Case history: A 83-year-old lady presented to acute admission unit with worsening of confusion. Her background medical history includes chronic obstructive pulmonary disease for which she is on inhalers. She was also having hyponatraemia for the last 3 years manifesting...

ea0082oc4 | Oral Communications | SFEEU2022

Barakat syndrome: A rare cause of primary hypoparathyroidism

Mark-Wagstaff Charlotte , Sathyapalan Thozhukat , Deshmukh Harshal

Case history: A 54-year-old lady was diagnosed with primary hypoparathyroidism in 2006, after being referred by her Rheumatologist as her father and brother had familial hypoparathyroidism and sensorineural deafness. She was followed up in endocrine clinic for management of primary hypoparathyroidism. Her hypocalcaemia is well managed with calcium supplementation, with no specific symptoms of hypocalcaemia. She has recurrent urinary tract infections with known borderline chro...

ea0065op4.3 | Bone and Calcium | SFEBES2019

Mendelian randomization and machine learning to assess the causal association of Type 2 Diabetes with osteoporosis and fragility fractures

Deshmukh Harshal , Papageorgiou Maria , Sathyapalan Thozhukat

Background: We used Mendelian randomization and machine learning (gradient boosting) to assess the causal association of Type 2 Diabetes with osteoporosis.Methods: We selected 155 SNPs associated with type 2 diabetes and glycaemic and insulin-related traits reported in previous studies (1,2) and studied the association with Heel bone mineral density (BMD)) (n= 4 72 996) and risk of fragility fractures (26 157 cases and 17 807 controls) in UKBiob...

ea0015p218 | Pituitary | SFEBES2008

Long term, high dose oestrogen treatment has no effect on prolactin levels and normalises gonadotrophin levels

Sathyapalan Thozhukat , Gonz'alez Susana , Atkin Stephen L

Context: Exogenous oestrogen administration causes prolactinoma formation in rats and there are anecdotal reports of oestrogen treatment and prolactinoma formation in gender reassignment males to females. It remains unclear whether chronic exposure to high dose oestrogen in women is linked with prolactinoma development.Aim: The aim of this study was to determine the effect of high dose subcutaneous estrogen on prolactin and gonadotrophin levels of 101 wo...

ea0077p23 | Adrenal and Cardiovascular | SFEBES2021

Feminizing adrenal tumours (FAT): Rare tumours of the adrenal gland

Mishra Ashish , Deshmukh Harshal , Shah Najeeb , Sathyapalan Thozhukat , Mongolu Shiva

Functioning adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with gynecomastia in the breast clinic. His serumbiochemistry showed persistently elevated Oestradiol and prolactin, with low testosterone and FSH. On physical examination, he had marked breast tenderness, bilateral gynecomastia and no signs of steroid excess. He reported a decline in ...

ea0077p109 | Reproductive Endocrinology | SFEBES2021

The relationship between polycystic ovarian syndrome and fractures: A Mendelian randomization study using the UK Biobank

Shah Najeeb , Deshmukh Harshal , Aye Mo , Sathyapalan Thozhukat

Background: Polycystic ovary syndrome (PCOS) is believed to be a primeval condition with the earliest hints of its existence found in ancient Egyptian literature. Despite its negative impact on fertility, it has emerged as the most common endocrine disorder in women of reproductive age, creating what is called the PCOS paradox. We hypothesized that this phenomenon can be explained by testosterone-mediated high bone mineral density (BMD) in women with PCOS, providing a survival...

ea0069p16 | Poster Presentations | SFENCC2020

Feminising adrenal tumours (FAT): the most common rare tumours of the adrenal gland?

Deshmukh Harshal , Shah Najeeb , Sathyapalan Thozhukat , Mongolu Shiva

Case history: Adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with bilateral gynecomastia in the breast clinic of, worsening over last one year. He had marked breast tenderness, a decline in his libido but no erectile dysfunction. There was no history of recreational drug use.Investigations: His serum biochemistry showed ...

ea0065p425 | Thyroid | SFEBES2019

Severe proximal myopathy with high creatine kinase levels secondary to Hashimoto’s thyroiditis

Shah Najeeb , Jervis William , Mongolu Shiva , Sathyapalan Thozhukat

A 30-year-old teacher with no past medical history presented with a 3 month history of muscle weakness, pain and spasms together with cold intolerance, weight gain and fatigue. She had a baby 4 months prior to this and 2 months after delivery noticed palpitations, insomnia and tiredness which resolved spontaneously. She was a non-smoker who did not consume alcohol. She was not on any medication. There was no family history of endocrinopathy. Clinical examination revealed proxi...

ea0038p354 | Reproduction | SFEBES2015

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis

Sathyapalan Thozhukat , David Rhiannon , Gooderham Nigel J , Atkin Stephen L

Introduction: MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules 18–24 nucleotides long that regulate gene expression at the post-transcriptional level. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS), with their differential expression depending on obesity. There is recent evidence that miRNA-93 and mi-RNA-223 may have a role to play in the modulation of insulin resistance, through GLUT4 modulation in...

ea0025p32 | Clinical biochemistry | SFEBES2011

Significance of insulin-C-peptide ratio in the diagnostic algorithm for endogenous hyperinsulinaemia

Sugunendran Suma , Narayanan Deepa , Shafiq Waqas , Malik Mohamed , Sathyapalan Thozhukat

Background: Insulin, derived from a single chain precursor pro-insulin, is cleaved by convertases to form insulin (t1/2 – 4 min) and C-peptide (t1/2 – 30 min). The ratio of insulin to C-peptide levels, which is usually less than one, is reversed in presence of exogenous insulin and insulin autoimmune syndrome. We present the significance of insulin-C-peptide ratio (ICR) in the diagnostic algorithm for the investigation of endogenous hyperinsulinaemia.<p class="ab...