Searchable abstracts of presentations at key conferences in endocrinology

ea0020p550 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly

Bianchi Antonio , Mazziotti Gherardo , Tilaro Laura , Cimino Vincenzo , Porcelli Teresa , Mormando Marilda , Tartaglione Linda , Pontecorvi Alfredo , Giustina Andrea , De Marinis Laura

Clinical trials have demonstrated that pegvisomant therapy is highly efficacious, normalizing serum IGF-I levels in the majority of patients with acromegaly. Multiple factors could influence the dose of pegvisomant required to normalize IGF-I, that ranging from 10 to 40 mg/day. However, the determinants of this variability are unknown and, to date, there is no specific recommendation to adjust the dose to the type of patient. Lack of exon 3 of the Growth Hormone receptor (d3-G...