Endocrine Abstracts

In this presentation I will discuss various aspects of hyperthyroidism during pregnancy. First of all, I will discuss that the epidemiology points towards a physiological underlying cause but I will also exhibit the differential diagnoses that should be addressed. Second, I will discuss preconception and gestational management of Graves’ disease, specifically focusing on new concepts regarding antithyroid drug choice, cessation and options in case of antithyroid drug fai...

In this talk I aim to provide a helicopter view of clinical studies on maternal thyroid function and child neurodevelopment and use this to pinpoint out how different viewpoints on the results can help to interpret the clinical relevance of the currently available data and provide handles to make personal but informed clinical decisions. It is well-established that thyroid hormone plays an important role during early stages of fetal brain development. Thyroid hormone-dependent...

During this presentation, I will share my views on the effects of maternal thyroid hormone on child brain development. I will discuss the physiology of maternal thyroid function during pregnancy and how this relates to time-dependent processes of fetal brain development. I will also discuss the various aspects of assessing fetal brain development. This is particularly important because we can only assessments fetal brain development in the children after birth, and we have to ...

Introduction: Although hCG is an important determinant of gestational thyroid function, it is unknown to what extent hCG is a risk factor for thyroid disease and we also lack knowledge on which characteristics influence the thyroidal response to hCG stimulation.Methods: hCG, TSH, FT4 and TPOAbs were measured in 5435 pregnant women (<18 weeks) in a prospective cohort. Subclinical disease entities were defined according to P2.5-P97.5 in TPOAb negative ...

Context: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide, affecting 2–8% of all pregnancies. We have previously shown that women with high-normal levels of FT4 during early pregnancy have a 2.1-fold increased risk of preeclampsia – but there was no apparent association with low TSH. However, the thyroid is stimulated by human chorionic gonadotropin (hCG) during early pregnancy and therefore we hypothesized that women with h...

Hyperprolactinaemia in association with a large sellar lesion could represent either tumoural secretion of prolactin (PRL) or stalk disruption by a non-prolactinoma: the differentiation has important therapeutic consequences. We have previously shown that based on currently used assays disconnection hyperprolactinaemia associated with non-functioning adenoma (NFA) practically never exceeds levels above 2000 mU/l. We aimed to verify our proposed disconnection hyperprolactinaemi...

Background: Thyroid hormone is an important regulator of fetal brain development. Low and high maternal free thyroxine concentrations during pregnancy have been associated with less grey matter and cortex volume. However, it remains unknown whether certain areas of the brain are differently affected. We used state-of-the-art brain MRI analyses in the largest mother-offspring imaging cohort worldwide to further elucidate how maternal thyroid function during early pregnancy affe...

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

Objective: Defining thyroid function test abnormalities in pregnancy is complicated by changes in maternal physiology. Ideally, reference intervals (RIs) should be population-based and pregnancy-specific. Large methodological differences between published reports limit the adoption of such RIs into clinical practice.Methods: The study was performed in the Consortium on Thyroid and Pregnancy. In line with current consensus and the 2017 American Thyroid As...

Thyroid disease during pregnancy is associated with adverse pregnancy outcomes and suboptimal fetal development. During the last decades, guidelines for diagnosing thyroid disease during pregnancy have changed considerably, and there has been increased awareness. This study aimed to describe the prevalence of thyroid disease treatment over time among pregnant women in Norway. We combined historical data from the Medical Birth Registry of Norway and the Norwegian Prescription D...