Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep800 | Reproductive and Developmental Endocrinology | ECE2020

Early decreases in testosterone levels in healthy adult men: A longitudinal analysis.

Banica Thiberiu , Verroken Charlotte , Zmierczak Hans-Georg , Goemaere Stefan , Reyns Tim , Fiers Tom , Kaufman Jean-Marc , Lapauw Bruno

Introduction: Although it is well-known that serum testosterone (T) levels decrease in ageing men, to this date no longitudinal data are available on changes in T levels in healthy young adult men.Objective: To investigate age-related longitudinal changes in serum levels of total T, free T and sex hormone binding globulin (SHBG) in healthy young men.Methods: Data from 999 healthy men aged 24–46years who participated in a long...

ea0071007 | Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study | BES2020

Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study

Thiberiu Banica , Charlotte Verroken , Tim Reyns , Ahmed Mahmoud , Guy T'Sjoen , Tom Fiers , Jean-Marc Kaufman , Bruno Lapauw

Background: Investigating longitudinal changes in serum androgen levels in healthy men in relation to (changes in) body composition, lifestyle factors and intercurrent illnesses.Methods: Longitudinal observational study. 999 healthy men aged 24–46 years of whom 691 were re-evaluated after a mean period of 12 years. Serum SHBG, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were measured using immuno-assays. Testosterone (T), ...

ea0081rc12.3 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Binding affinity affecting SHBG SNPs do not majorly affect calculated estimates of free testosterone

Walravens Joeri , Banica Thiberiu , Van Den Eynde Tibbert , Snaterse Gido , Reyns Tim , Narinx Nick , Antonio Leen , Fiers Tom , Kaufman Jean-Marc , Lapauw Bruno

Introduction: According to the free hormone transport hypothesis, only free testosterone (FT) is considered biologically active. Due to low circulating levels and technical challenges of direct FT measurements, calculators have been developed to estimate FT from serum total T, sex hormone-binding globulin (SHBG) and albumin levels. However, genetic polymorphisms altering SHBG’s binding affinity or capacity might result in calculation imprecisions with consequent incorrect...

ea0088012 | Abstracts | BES2022

Changes in serum androgen levels in transgender women with and without gonadectomy

Sarah Collet , Noor Gieles , Chantal M Wiepjes , Annemieke C Heijboer , Tim Reyns , Tom Fiers , Bruno Lapauw , Martin den Heijer , Guy T'Sjoen

Introduction: Transgender women on gender-affirming hormone therapy (GAHT) with estrogens and anti-androgens have low serum androgen levels. These low levels may be associated with clinical symptoms such as depressed mood, reduced sexual desire and tiredness. Whether androgen levels change over the course of anti-androgen use and after gonadectomy, in a context of unchanged estrogen treatment, remains to be elucidated.Methods: This study is part of the E...