Searchable abstracts of presentations at key conferences in endocrinology

ea0056p692 | Clinical case reports - Pituitary/Adrenal | ECE2018

Delayed puberty vs hipogonadotropic hypogonadism; how long to wait to treat?

Munoz-Garach Araceli , Diaz-Perdigones Cristina , Cornejo-Pareja Isabel , Mancha-Doblas Isabel , Tinahones Francisco J

We presented the case of a 21 years old patient, derived from Primary Care to evaluate low testosterone levels (total testosterone (TT) 0.44 ng/ml). His father had delayed pubety and his mother menarche was at 11 years. No other personal history of interest. He had adequate child development and vaccination. No parotiditis. He referred some morning erections. Weight 59 kg, size 171 cm and BMI 20.17 kg/m2. Testes volume (TV) of 4-5 cc, scanty pubic hair. Tanner stage...

ea0081p621 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Phase angle, a raw bioelectrical impedance analysis (bia) variable, as a prognostic factor for mortality at 90 days in patients with covid-19

Cornejo-Pareja Isabel , Vegas-Aguilar Isabel Ma , Garcia-Almeida Jose Manuel , Fernandez Valero Andrea , Tinahones Francisco J

Introduction: COVID-19 has taken on pandemic proportions. Phase angle (PhA) and Standardized phase angle (SPhA) have been related to mortality and severity in several diseases.Objetives: To determine the predictive role of PhA and SPhA on 90 days survival of adults with COVID-19.Methods: A longitudinal cohort study with 127 consecutive patients diagnosed with COVID-19. We collected PhA, SPhA, body composition (fat mass, fat free ma...

ea0063p548 | Diabetes, Obesity and Metabolism 2 | ECE2019

Microbiota changes in type 2 diabetes patients intolerant to metformin after drug reintroduction

Munoz-Garach Araceli , Diaz-Perdigones Cristina Maria , Moreno-Indias Isabel , Molina-Vega Maria , Cornejo-Pareja Isabel , Tinahones Francisco J

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

ea0070aep475 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Descriptive analysis of body composition and phase angle (PA) in achondroplastic patients: Case-control study

Mª Vegas-Aguilar Isabel , Maria Cornejo Pareja Isabel , Leiva Gea Antonio , Tinahones Francisco J , Manuel García-Almeida Jose

Introduction: Data on body composition in patients with achondroplasia are scarce. The Phase Angle (PA) is a bioelectric measurement of our body cells. The PA is considered to be a global prognostic factor that gives information about cellular function in relation to body composition.Objectives: To describe body composition parameters PA, standardized PA (sPA), resistance (Rz), reactance (Xc), body cell mass (BCM), total body water (TBW), fat mass (FM), ...

ea0056p585 | Obesity | ECE2018

Relationship between human adipose tissue autophagy, obesity and glycemic status

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Lhamyani Said , Gentile Adriana-Mariel , Alcaide-Torres Juan , bekay Rajaa El , Tinahones Francisco J

Introduction and aims: Autophagy is an essential process for cell homeostasis that implies recycling and degradation of damaged organelles and long-lived proteins. It is induced during caloric restriction (in order to obtain energy) or other stress-inducing conditions. Autophagy is initiated by autophagosome formation, a double-membrane vesicle which engulfs cellular components and delivers them for degradation by fusing with lysosomes. Thus, proper autophagy regulation favour...

ea0081p57 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diagnosis of gestational diabetes mellitus in the COVID-19 pandemic: comparative analysis of women with positive O’Sullivan test in the same trimester of 2019 and 2020

Ignacio Martinez Montoro Jose , Jose Simon Frapolli Victor , Molina Vega Maria , Espina Sonsoles Morcillo , Suarez Arana Maria , Tinahones Francisco J. , Jose Maria , Cesar Picon

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

ea0081p240 | Thyroid | ECE2022

Development of a laboratory alerting system for the early diagnosis of thyroid dysfunction in pregnancy

Ignacio Martinez Montoro Jose , Jose Simon Frapolli Victor , Fernandez Valero Andrea , Molina Vega Maria , Cobos Andres , Tinahones Francisco J. , Jose Picon Cesar Maria

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...

ea0063p717 | Pituitary and Neuroendocrinology 2 | ECE2019

Glycogenosis and hypofisis pathology, importance of a multidisciplinary management

Cornejo-Pareja Isabel , Maraver-Selfa Silvia , Munoz-Garach Araceli , Gonzalo-Marin Montserrat , Hernandez-Garcia Carmen , Damas-Fuentes Miguel , Mancha-Doblas Isabel , Tinahones Francisco J

Introduction: Glycogenosis is a group of hereditary diseases affecting the glycogen metabolism, due to mutations in enzymes involved in the transformation and synthesis of glucose (liver and muscle glycogenosis). Brain germ tumors are very infrequent. They are located mainly in pineal and sellar region. Central diabetes insipidus is the most frequent manifestation. Their prognosis and response to combined chemo/radiotherapy treatment are favorable.Case r...

ea0041ep783 | Obesity | ECE2016

Relationship between lipopolysaccharide levels and the gene expression profile in adipose tissue from morbidly obese patients

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Oliva-Olivera Wilfredo , Alcaide-Torres Juan , Fernandez-Garcia Jose-Carlos , Cardona Fernando , Tinahones Francisco J

Introduction: Obesity is characterized by a low-grade inflammatory state which has been directly related to the development of insulin resistance and diabetes. Circulating lipopolysaccharides (LPS) have been proposed as a triggering factor for this inflammation. Likewise, adipose tissue (AT) capacity for lipid handling and storage is also a key factor for the development of obesity-related metabolic disorders. Animal studies have shown that LPS are able to modify the expressio...

ea0041ep804 | Obesity | ECE2016

Medium-term evolution of ghrelin levels according to three types of bariatric surgeries and its relation with HDL and insulin resistance

Santiago-Fernandez Concepcion , Garcia-Serrano Sara , Tome Monica , Valdes Sergio , Ocana-Wilhelmi Luis , Rodriguez-Canete Alberto , Tinahones Francisco J. , Garcia-Fuentes Eduardo , Garrido-Sanchez Lourdes

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...