Endocrine Abstracts

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Backgrounds: One of the most observations in subjects with obesity, is a high prevalence of vitamin D deficiency, which, in turn, it has been implicated with decreased testosterone levels and an increased hypogonadism risk. Testosterone deficiency is a very common feature in males with obesity. However, only few studies have investigated the effect of vitamin D on testosterone in the context of obesity, and controversial results has been found.Hypothesis...

Introduction: Flash glucose monitoring expansion to an increasing number of patients with type 1 diabetes, coupled with its increased accuracy and ease of use, has increased available data on glycemic control in this population and allows detection of improvement areas in diabetes education and treatment.Objective: To analyze main parameters standardized by ATTD consensus (2019) in our population of patients with type 1 diabetes using flash glucose monit...

Introduction: 25-hydroxyvitamin D (25(OH)D3) deficiency has been associated with diabetes and obesity. However, the mechanisms underlying these relationships are not completely understood. Vitamin D receptor (VDR) is expressed in adipose tissue; it has been reported a higher expression in obese patients than in lean subjects, suggesting a differential vitamin D dynamics in adipose tissue according to the obesity degree. In addition, 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) is a...

Introduction: A two-step approach is usually used to diagnose GDM. At 24–28 weeks of pregnancy, a 50 g 1-hour glucose or O’Sullivan test is performed. If it is positive (≥140 mg/dl), it is followed by a 100 g-3 hours-Oral Glucose Tolerance Test (OGTT) which is considered positive if at least two or more values are ≥ of reference values (105-190-165-145 mg/dl). Despite it is not include in any clinical practice guideline, sometimes the 100 g OGTT is obviat...

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is present in a high percentage of obese patients undergoing bariatric surgery (BS), being an effective strategy for the remission of MAFLD. A significant proportion of patients still have steatohepatitis even after considerable weight loss and metabolic improvements. Liver biopsy remains the definitive test to classify a patient with steatohepatitis, but it is an invasive test. The use of non-invasive ...

Introduction: Vitamin D deficiency is a common health problem worldwide, particularly in elderly patients. Vitamin D is considered a key hormone in mineral and bone metabolism, as well as in functions such as the regulation of cell proliferation and differentiation, its immunoregulatory activity, its effect on the cardiovascular system and its neuroprotective and anti-ageing effects, among others. Hypovitaminosis D has been linked in multiple studies to a higher incidence and ...

Introduction: Percutaneous ethanol injection (PEI) or thyroid enolisation is a minimally invasive technique applicable to benign cystic thyroid nodules, not adhered to neighbouring structures, due to local compressive symptoms or aesthetic discomfort. Classically, the treatment of choice for these nodules has been simple aspiration, followed by surgery in refractory cases. Currently, PEI has emerged as an alternative to surgery due to its high efficacy, speed, safety, low rate...

Introduction: Vitamin D is considered a fat-soluble vitamin and a fundamental prohormone in mineral and bone metabolism, with an immunoregulatory, cardiovascular and neuroprotective effect, among others. Vitamin D can be found as vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. The main source of vitamin D comes from ultraviolet radiation in sunlight, but it is also obtained through food. Vitamin D deficiency is very prevalent in Europe, with a significant peak ...