Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep750 | Pituitary: clinical | ECE2015

Rate of Prolactin suppression can predict future prolactin normalisation, tumour shrinkage and time to remission in male macroprolactinomas

Tirosh Amit , Benbassat Carlos , Shimon Ilan

Introduction: Dopamine agonists are the mainstay treatment for prolactinomas, but clinical characteristics that predict their effects on prolactin (PRL) suppression and tumour shrinkage are missing. Our study aimed to find measures in early follow-up of men harbouring macroprolactinomas, that will predict dynamics of PRL decrease and adenoma shrinkage.Methods: A single centre historical prospective study, including a consecutive group of 71 men with pitu...

ea0081p637 | Endocrine-Related Cancer | ECE2022

Sporadic and Von Hippel-Lindau disease-related pancreatic neuroendocrine tumors definitions are not consistent between the various classification criteria

Halperin Reut , Eden-Friedman Yehudit , Arnon Liat , Tirosh Amit

Background: von Hipple-Lindau (VHL) disease comprises hemangioblastomas, renal cell carcinomas (RCC), pheochromocytomas, and pancreatic neuroendocrine tumors (PNET). Diagnosis is based International (two hemangioblastomas, one hemangioblastoma and one visceral lesion, or VHL family history and hemangioblastoma or visceral lesion) or Danish criteria (any two clinical manifestations, one clinical manifestation and family background of VHL or self-genetic diagnosis). The nature o...

ea0049gp186 | Pituitary & endocrine Tumours | ECE2017

24 hour urinary 5-hydroxyindoleacetic acid (5-HIAA) doubling-time (DT) is associated with disease-specific mortality (DSM) and progression-free survival (PFS) in patients with neuroendocrine tumors (NETs)

Tirosh Amit , Nilubol Naris , Patel Dhaval , Kebebew Electron

Background: Biochemical biomarker DT is used clinically for prognosis prediction in several solid malignancies. The aim of the current analysis was to determine whether biomarker DT has any prognostic utility in patients with NETs.Methods: Patients with NETs (n=184) were enrolled in a prospective study with comprehensive biochemical analysis. The current analysis included subjects with increasing 5-HIAA levels in at least two consecutive measure...

ea0037gp.20.03 | Pituitary – Hypopituitarism | ECE2015

Timing is everything? Postpartum pituitary dysfunction – variability of clinical and radiological presentation

Tirosh Amit , Iraqi Hiba Masri , Hirsch Dania , Robenshtok Eyal , Yoel Uri , Toledano Yoel , Twito Orit , Tsvetov Gloria , Shimon Ilan

Introduction: Two aetiologies are responsible for postpartum hypopituitarism; Sheehan’s syndrome which develops following traumatic labour, and lymphocytic hypophysitis. Since management of lymphocytic hypophysitis does not require surgery in most cases, pathology is usually absent, and the clinical presentation, in combination with laboratory and imaging characteristics establish the diagnosis. We aimed to describe the various patterns of presentation, including assistin...

ea0049gp124 | Endocrine Tumours | ECE2017

VHL Genotype and risk stratification of pancreatic neuroendocrine tumors in patients with von hippel-lindau disease

Tirosh Amit , Shell Jasmine , Green Patience , Keutgen Xavier M. , Sadowski Samira M. , Lakis Mustapha el , Nockel Pavel , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: About 8–20% of patients with von Hippel-Lindau disease (vHLd) develop pancreatic neuroendocrine tumors (PNETs). However, prognostic markers for these tumors are lacking. The VHL gene mutation type is associated with the clinical phenotype of vHLd. Hence, we aimed to determine whether VHL mutation characteristics may be associated with PNETs phenotype in patients with vHLd.Methods: A prospective study of patients with vHLd and PNETs with ...

ea0049ep13 | Adrenal cortex (to include Cushing's) | ECE2017

Hair cortisol in patients with primary aldosteronism

Hodes Aaron , Lodish Maya , Tirosh Amit , Meyer Jerrold , Belyavskaya Elena , Lyssikatos Charalampos , Rosenberg Kendra , Demidowich Andrew , Swan Jeremy , Jonas Nichole , Stratakis Constantine , Zilbermint Mihail

Context: Primary aldosteronism (PA) is a common cause of secondary hypertension, and some PA adrenal tumors co-secrete glucocorticoids, causing subclinical or overt Cushing syndrome (CS). We recently reported correlations between hair cortisol concentration (HCC) and serum and urinary levels of cortisol in patients with CS.Objective: To determine correlations of segmental hair cortisol and biochemical markers of a referred cohort of patients for the eval...

ea0049oc7.3 | Cardiovascular endocrinology (1) | ECE2017

High Total 68Ga-DOTATATE-Avid Tumor Volume (TV) is associated with low progression-free survival and high disease-specific mortality rate in patients with neuroendocrine tumors

Tirosh Amit , Papadakis Georgios Z. , Millo Corina , Sadowski Samira M. , Herscovitch Peter , Pacak Karel , Marx Stephen J. , Yang Lily , Nockel Pavel , Shell Jasmine , Green Patience , Keutgen Xavier M. , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: Patients with neuroendocrine tumors (NETs) have divergent survival, even when having the same site of primary tumor, and tumor stage and grade. 68Gallium (68Ga)-DOTATATE positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging modality for detecting NETs. The purpose of this study was to determine whether 68Ga-DOTATATE PET/CT imaging has any prognostic utility in patients with NETs.Methods: One hundred and eighty-fou...