Searchable abstracts of presentations at key conferences in endocrinology

ea0033oc2.10 | Oral Communications 2 | BSPED2013

A new approach to the definition and diagnosis of adrenal insufficiency during inhaled corticosteroid therapy for asthma

Blair Jo , Didi Mohammed , Lancaster Gillian , Titman Andrew , Newland Paul , Collingwood Catherine , Peak Matthew , Couriel Jonathon

Background: Up to 50% of children treated with inhaled corticosteroids (ICS) have biochemical evidence of adrenal insufficiency (AI). Episodes of adrenal crisis (AC) are extremely rare.To address the discordance between the prevalence of biochemical AI and AC, we re-examined the biochemical definition of AI during ICS therapy. We then investigated the utility of early morning salivary cortisol (EMSC) and cortisone (EMSCn) for the identification of patien...

ea0039ep2 | Adrenal | BSPED2015

Between patient and inter-time point variability in salivary cortisone: cortisol ratios

Park J , Lancaster G , Titman A , Peak M , Newlands P , Collingwood C , Chesters C , Moorcroft T , Hawcutt D , Didi M , Couriel J , Blair J

Background: Salivary biomarkers are attractive diagnostic tools for paediatric practice, enabling non-invasive sampling at home. Salivary cortisol (SCl) and cortisone (SCn) are sensitive markers of adrenal insufficiency during inhaled corticosteroid treatment(1). SCn is reported to be the best correlate of plasma cortisol. Measurements of SCl may not be necessary, reducing cost and sample volumes.Eleven beta hydroxysteroid dehydrogenase type 2...