Searchable abstracts of presentations at key conferences in endocrinology

ea0085nep2.1 | Endocrine Symposium 4 | BSPED2022

Immune dysregulation driving future risk of disease in children with obesity

DeBarra Conor , Tobin Laura , O'Shea Donal , Cody Declan , Hogan Andrew

Obesity is linked to an increased risk of 13 different cancers in adulthood. The environment supporting this increased risk is multi-factorial but includes metabolic dysregulation, chronic inflammation and the loss of the anti-tumour activity of cells such natural killer (NK) cells. We present data which shows that this pro-cancer environment starts early in children with obesity, potentially increasing their risk of future disease. We investigated a cohort of 50 children with...

ea0049ep696 | Obesity | ECE2017

GLP-1 therapy and the immune system – can we predict responders from non-responders?

O'Shea Donal , Tobin Laura , Cody Declan , Mat Arimin , Kinlen David , Hogan Andrew

Abstract: Obesity has reached epidemic proportions globally. At least 2.8 million people die each year as a result of being overweight or obese, the biggest burden being obesity-related diseases. Glucagon like peptide 1 (GLP-1) targeted therapies show the greatest potential for intervention and are approved as weight loss agents. However not all patients respond to GLP-1 therapy. Understanding the mechanisms of bodyweight regulation and their role in GLP-1 responders vs. non-r...

ea0035p499 | Diabetes therapy | ECE2014

Differential effects of native Peptide YY and its long acting analogue (Y-59) on innate lymphocyte function and anti-tumour activity

Hogan Andrew , Tobin Laura , Corrigan Michelle , Gilshinan Colm , Ghatei Mohammad , Bloom Stephen , O'Shea Donal

Background: Peptide-YY is synthesised and secreted by specialised cells in the ileum and colon. Levels increase following food intake, having a satiety effect. Baseline and postprandial levels of PYY were found to be lower in obese subjects compared to lean, negatively correlating with the subjects BMI, however obese subjects were sensitive to the anorectic effects of PYY when given exogenous PYY.Hypothesis: We have recently demonstrated that another pra...