Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep792 | Endocrine tumours and neoplasia | ECE2017

Chronic stress and somatotroph axis in breast cancer more than a simple association

Crumpei Iulia , Armasu Ioana , Danciu Mihai , Tofan Mariana , Volovat Constantin , Belceanu Alina , Crumpei Felicia , Adomnicai Valentina , Vulpoi Carmen

Introduction: Epidemiological and clinical studies have proven direct correlations between chronic stress, inflammation and cancer progression. The inflammatory environment preexisting the malignant change and elevated IGF-1 levels are associated with higher cancer risk, especially through GH effects on cell proliferation and inhibition of apoptosis.Aim: To evaluate the relationship between biological and hormonal stress markers, growth factors and breas...

ea0049ep809 | Obesity | ECE2017

Obesity, gonadotropic axis and breast cancer – is ghrelin the connexion?

Armasu Ioana , Crumpei Iulia , Volovat Constantin , Tofan Mariana , Zaharia Valentin , Aancutei Adrian , Vasiliu Ioana , Lacramioara Serban Ionela , Vulpoi Carmen

Introduction: Obesity and insulin resistance have been identified as risk factors for breast cancer and are associated with late-stage diagnosis and poor prognosis. Ghrelin is a unique gut-derived peptide that has major impact in energy homeostasis and weight regulation, with new emerging implications in tumorigenesis process, especially in hormone-dependent cancers.Aim: To evaluate the relationship between ghrelin, clinico-biological parameters of obesi...

ea0037ep626 | Obesity and cardiovascular endocrinology | ECE2015

Obesity and breast cancer – does size matter?

Armasu Ioana , Crumpei Iulia , Volovat Constantin , Belceanu Alina Daniela , Constantinescu Georgiana Andreea , Tofan Mariana , Ungureanu Maria Christina , Leustean Letitia , Vulpoi Carmen

Introduction: The epidemic of obesity has risen many health concerns, beneath the metabolic syndrome. One of these problems is the effect of obesity on cancer evolution. Populational studies have shown a direct correlation of BMI with worse prognostic, life quality and occurrence of comorbidities in neoplastic diseases, one of the most studied being breast cancer.Patients and methods: We retrospectively analysed the evolution of postmenopausal obese and ...