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ea0028oc5.5 | Growth, tumours and pituitary | SFEBES2012

Role of the hypoxic signalling pathways in the histopathological prediction of malignancy in phaeochromocytomas and paragangliomas

Pinato David , Ramachandran Radha , Toloue Kalami Toussi Samin , Vergine Marco , Ngo Nyethane , Sharma Rohini , Khoo Bernard , Meeran Karim , Palazzo Fausto , Martin Niamh , Dina Roberto , Tan Tricia

Backgeound and Aims: Phaeochromocytomas (PCC) and paragangliomas (PGL) are mostly benign sympathoadrenal tumours. However, there are no available markers to predict a malignant course. Since hypoxia is involved in the pathogenesis of these tumours, we aimed to qualify the relevance of the mammalian Target of Rapamycin (m-TOR) and hypoxic pathways in benign and malignant PCC/PGL.Methods: Tissue microarray (TMA) blocks were constructed with 80 PCC/PGL, inc...

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Role of the hypoxic signalling pathways in the histopathological prediction of malignancy in phaeochromocytomas and paragangliomas

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