Endocrine Abstracts

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Introduction: Endocrinopathy is frequently seen in systemic amyloidosis and commonly involves thyroid and gonads. We report a case of primary adrenal failure secondary to systemic light chain amyloidosis (AL), involving kidney, liver, spleen, gut, nerves and tongue.Case: A 42-year-old Somalian lady presented with 2-year history of lethargy, febrile episodes and 21 kg weight loss. Investigations showed increase in serum lambda light chain 103 mg/l (5.7&#1...

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...

Aim: Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance imaging (MRI) based method to identify human BAT and delineate it from white adipose tissue (WAT), and validate it by providing immunohistochemical confirmation.Methods: Initial scanning with 18F-FDG PET–CT radiotracer uptake on a 25-year-old Caucasian female wit...