Searchable abstracts of presentations at key conferences in endocrinology

ea0099rc9.5 | Rapid Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Pregnancy and acromegaly: Clinical outcomes of retrospectively analysed data from the German Acromegaly Registry

Tonjes Anke , Wurfel Marleen , Quinkler Marcus , Knappe Ulrich , Honegger Jurgen , Krause.Joppig Nina , Bacher Konrad , Schopohl Jochen , Stormann Sylvere , Meyhofer Sebastian

Context: Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion, mostly induced by pituitary adenomas. The care of pregnant women with acromegaly is challenging, in part due to existing clinical data being limited and not entirely consistent with regard to potential risks for mother and child.Objective: To retrospectively examine data on pregnancy and maternal as well as neonatal outcomes in patients with acromegaly.<p class="...

ea0056p859 | Pituitary - Clinical | ECE2018

PROMPT: a prospective study to assess efficacy and safety of metyrapone in endogenous Cushing’s syndrome

Nieman Lynnette , Akinci Baris , Beckers Albert , Bolanowski Marek , Hanzu Felicia Alexandra , Mezosi Emese , Tonjes Anke , Bostnavaron Martine , Jaspart Amelie , Borensztein Pascale , Boscaro Marco , Scaroni Carla

Introduction: Metyrapone blocks cortisol production by inhibiting 11ß-hydroxylation of 11-deoxycortisol, the last step of cortisol synthesis. Based on observational retrospective studies published over more than 50 years metyrapone is approved for the treatment of endogenous CushingÂ’s syndrome (CS) in 14 European countries. PROMPT is the first prospective study to document the safety and efficacy of metyrapone using modern assay techniques.Desi...

ea0099rc3.2 | Rapid Communications 3: Adrenal and Cardiovascular Endocrinology | Part I | ECE2024

Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias – The prospective cross-sectional diagnostic test performance study FAMIAN

Hahner Stefanie , Hartrampf Philipp , Beuschlein Felix , Miederer Matthias , Miehle Konstanze , Wiebke Schlotelburg , Fuss Carmina Teresa , Pflmger Thomas , Fottner Christian , Tonjes Anke , Herrmann Ken , Amthauer Holger , Schreckenberger Mathias , Sabri Osama , Werner Johanna , Reuter Miriam , Kircher Stefan , Arlt Wiebke , Fassnacht Martin , Buck Andreas , Muller Hans Helge , Andreas Schirbel

Adrenal tumours are frequently detected by conventional cross-sectional imaging, which, however, has limited specificity in identifying the most prevalent tumour type, benign, non-functional adrenocortical adenomas (ACA) not requiring surgery. We assessed the diagnostic accuracy of adrenal molecular imaging with [18F]Fluorodeoxyglucose-positron emission tomography (FDG-PET) and [123I]Iodometomidate-single photon emission tomography (IMTO-SPECT). We perfor...