Searchable abstracts of presentations at key conferences in endocrinology

ea0048cb6 | Additional Cases | SFEEU2017

Complex thyroid cancer with likely underlying TSHoma – a medical challenge

Kempegowda Punith , Ayuk John , Toogood Andy , O'Reilly Michael , Boelaert Kristien

A 22-year-old Caucasian female was referred to thyroid specialist clinic due to difficulties fully suppressing her thyroid stimulating hormone (TSH) despite high dose combination therapy of triiodothyronine (T3) and thyroxine (T4) treatment. She had a well-differentiated thyroid -carcinoma of left thyroid lobe treated with left lobectomy. Several other small primary thyroid carcinoma lesions were detected on further examination of the histology which lead to completion thyroid...

ea0034p287 | Pituitary | SFEBES2014

An evolution of clinical practice: the impact of changes in clinical management of non-functioning pituitary adenomas on long-term pituitary function and risk of recurrence

O'Reilly Michael , Pearce Harriet , Bugg Gabriella , Mitchell Rosalind , Toogood Andy , Gittoes Neil , Ayuk John

Management of newly-diagnosed non-functioning pituitary adenomas (NFPAs) has evolved over the last decade. Whilst surgical debulking remains the mainstay of treatment for patients presenting with compressive disease, the use of pituitary irradiation has declined, with greater emphasis on observation or further surgical debulking. We aimed to compare outcomes of treatment for NFPAs at our institution since 2004 with older management strategies.We reviewed...

ea0013oc21 | Novartis Basic Endocrinology Award | SFEBES2007

Muscle cell differentiation is regulated by glucocorticoids, a process which is potentiated through the induction of 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

Sherlock Mark , Lavery Gareth , Horsburgh Jenny , Slabbert Ana , Toogood Andy , Stewart Paul

In vivo the 11β-HSD1 enzyme converts inactive cortisone to the active glucocorticoid cortisol. 11β-HSD1 is implicated in the metabolic syndrome through its expression in liver and adipose tissue by increasing local cortisol concentrations. However, little is known regarding the expression and function of 11β-HSD1 in muscle.Murine C2C12 muscle cells (myocytes) were differentiated from myoblasts to myotubules for 8 days, with and without the...

ea0059p138 | Neuroendocrinology and pituitary | SFEBES2018

Outcomes of bilateral adrenalectomy in ACTH-dependent Cushing’s syndrome

Samani Niraj , Fountas Athanasios , Chai Shu Teng , Gleeson Helena , Ayuk John , Arlt Wiebke , Toogood Andy , Gittoes Neil , Karavitaki Niki

Introduction: Bilateral adrenalectomy (BADx) is a treatment option in ACTH-dependent Cushing’s syndrome refractory to other therapeutic modalities or can be an emergency measure in cases with severe manifestations of hypercortisolaemia.Aim: To review the outcomes of our patients with ACTH-dependent Cushing’s offered BADx.Methods: Records of patients with ACTH-dependent Cushing’s managed by BADx and seen in our Depart...

ea0065p292 | Neuroendocrinology | SFEBES2019

Cabergoline in the treatment of acromegaly: experience from a large pituitary centre

Samperi Irene , Lithgow Kirstie , Chai Shu Teng , Asia Miriam , Ahmed Shahzada , Paluzzi Alessandro , Tsermoulas George , Meade Sara , Sanghera Paul , Toogood Andy , Gittoes Neil , Ayuk John , Karavitaki Niki

Introduction: Cabergoline is one of the medical treatments in acromegaly; it can be used alone or in combination with other available agents.Aim: To review the efficacy of cabergoline in patients with acromegaly treated in our centre.Patients and methods: Patients with acromegaly on cabergoline were identified from our Pituitary Registry. Clinical/laboratory/imaging data were collected and analysed.Results: F...

ea0065p284 | Neuroendocrinology | SFEBES2019

Silent somatotroph pituitary neuroendocrine tumours (PitNETs): systematic review of cases from a Pituitary Centre

Nazir Muneer Ahmad Abdul , Fountas Athanasios , Lithgow Kirstie , Ayuk John , Toogood Andy , Gittoes Neil , Senthil Latha , Chew Han Seng , Chavda Swarupsinh , Matthews Tim , Batra Ruchika , Ahmed Shahzada , Paluzzi Alessandro , Tsermoulas George , Nagaraju Santhosh , Pohl Ute , Karavitaki Niki

Introduction: Silent somatotroph Pituitary Neuroendocrine Tumours (PitNETs) are extremely rare (2−3% of surgically treated pituitary tumours) and data on their natural history and outcomes are scarce.Aim: To review systematically the cases of these tumours presenting in our Centre.Patients and methods: Patients with this diagnosis were identified from our Pituitary Registry and clinical/laboratory/imaging data were collected ...

ea0065p315 | Neuroendocrinology | SFEBES2019

The spectrum of testosterone levels in males with functioning gonadotroph adenomas: report of three cases

Fountas Athanasios , Samperi Irene , Webster Rachel , Asia Miriam , Ahmed Shahzada , Paluzzi Alessandro , Tsermoulas George , Senthil Latha , Chew Han Seng , Chavda Swarupsinh , Matthews Tim , Batra Ruchika , Ayuk John , Toogood Andy , Gittoes Neil , Karavitaki Niki

Introduction: Functioning gonadotroph adenomas (FGAs) are very rare tumours secreting biologically active gonadotropins. In males, typically, FSH levels are elevated, whereas LH and testosterone are variable. Herein, we present three males with elevated, normal or low testosterone at diagnosis.Cases: Case 1:42-year-old man with two-year history of visual impairment. Bitemporal hemianopia was confirmed. Imaging showed macroadenoma compressing optic chiasm...