Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep959 | Thyroid | ECE2022

Graves’ orbitopathy caused by alemtuzumab: a case series

Mendez Muros Mariola , Jesus Garcia Gonzalez Juan , Cuadrado Alberto Torres , Manuel Garrido Hermosilla Antonio

Introduction: Alemtuzumab is a monoclonal antibody targeting the CD52 glycoprotein, which is expressed by most mature leucocytes. In early relapsing-remitting multiple sclerosis (MS) alentuzumab effectively decreases relapse rate and disability progression. However, nearly 50% of the pacients treated with alentuzumab develop secondary autoimmune disorders, being Graves’ disease the most common. The development of thyroid eye disease is unusual.Aims ...

ea0037gp.25.07 | Thyroid – nodule | ECE2015

Malignancy risk stratification of thyroid nodules by TIRADS; correlation with cytological results

Martinez Antonio J , Hernando Virginia , Garcia Clara , Torres Alberto , Martin Tomas

Introduction: Knowing that only in 5–15% of FNABs the pathological analysis shows malignancy, enhance diagnostic accuracy is needed. The use of the TIRADS score and a revised version proposed by the British Thyroid Association (BTA) intend to determine if a FNAB should be performed or not in the evaluation of nodular goitre.Objective: To determine whether an adequate correlation is present between the risk category assigned to the nodules studied un...

ea0016p692 | Thyroid | ECE2008

Rosiglitazone in two patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer

Martin Tomas , Fernandez-Arguelles Amaya , Torres Alberto , Gentil Alfonso , Castro Juan , Cambils Teresa

Thiazolidinediones have demonstrated some efficacy in promoting radioiodine uptake of previously poorly radioiodine-responsive thyroid cancers. We describe the effect of rosiglitazone, in promoting uptake in thyroid metastatic tissue with weak uptake in order to treatment with radioiodine in two patients.Case 1: A 62-year-old woman with thyroid cancer and negative I-131 body scan post therapy (150 mCi) with presence of recurrent disease (PET positive in ...

ea0014p334 | (1) | ECE2007

Hashimoto’s encephalitis: role of diagnostic SPECT

Martin Tomas , Gentil Alfonso , Torres Alberto , Maraver Silvia , Diaz-Galvez Milagrosa

In autoimmune thyroid disease some diverse neurological alterations like dementia, psychosis or peripheral neuropathy, are described. Hashimoto’s encephalopathy (EH) is a serious form of these neurological alterations. We describe three cases with different presentation and morphologic normal tests where cerebral SPECT was diagnostic.Case n°1. A 32-year-old male diagnosed of autoimmune hypothyroidism which presents paresthetics and muscular sti...

ea0032p1112 | Thyroid cancer | ECE2013

Ultrasound guided enolization as a therapeutic alternative in local recurrences of papillary thyroid carcinoma

Hernandez Tomas Martin , Rodriguez Jose Perez , Rivera Natividad Gonzalez , Cuadro Alberto Torres , Garcia Clara Garcia , Manzano Virginia Martin

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

ea0037gp.23.04 | Thyroid – diagnosis | ECE2015

Impact of antithrombotic and/or anticoagulant treatment in cytological results of thyroid fine-needle biopsy

Molina Carlos Arana , Cuadro Alberto Torres , Rivera Natividad Gonzalez , Garcia Clara Garcia , Jimenez Virginia Hernando , Ojeda Luna Florencio , Hernandez Tomas Martin

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...

ea0037ep870 | Thyroid cancer | ECE2015

Chemotherapy effectiveness in the treatment of non-medullary well-differentiated thyroid cancer: a systematic and case review

Albero Ana , Martin Esther , Torres Alberto , Garcia Teresa , Gonzalez Natividad , de Carmen del Alamo Maria , de la Cruz Luis , Martin Tomas

Introduction: Nowadays, use of chemotherapy in well-differentiated non medullary thyroid cancer, locally advanced stage and/or with radioiodine-refractory metastases is considered of scanty value. However, in the last 40 years was not published any phase III study nor a systematic review of its use in clinical setting.Methods: A systematic literature search was performed in databases such as Medline and Embase, among others. Two independent reviewers ana...

ea0035p51 | Adrenal cortex | ECE2014

The adrenal venous sampling is a difficult test in the localization of the primary hyperaldosteronism

Rodriguez Jose Perez , Jimenez Virginia Hernando , Hernandez Tomas Martin , Cuadro Alberto Torres , Rivera Natividad Gonzalez , Baldrich Alfonso Gentil , Cobos Manuel Malagon

Introduction and objectives: The localization of primary hyperaldosteronism is often difficult. The coexistence of nonfunctioning adenomas is common in patients older 40 years old and small adenomas undetectable by CT could confuse with bilateral hyperplasia. The AVS is considered the ‘gold standard’ test for the location of numerous guides. We describe our experience in a clinical case of primary aldosteronism.Clinical case: We present a 58 ye...

ea0035p597 | Endocrine tumours and neoplasia | ECE2014

Everolimus in monotherapy as a therapeutic option in paragangliomas/pheochromocytomas

Cuadro Alberto Torres , Rodriguez Jose Perez , Tamarit Ana Albero , Hernandez Tomas Martin , Rivera Natividad Gonzalez , Zoilo Juan Jose Reina , Carrasco Fernando Henao , Merino Luis De La Cruz

Introduction: Everolimus is a drug selective inhibitor of mTOR. In 2012 a Phase 2 study* of everolimus monotherapy demonstrated modest efficacy in patients with pheochromocytomas/paragangliomas. Our objective was to evaluate the efficacy and safety of everolimus in a patient with paraganglioma. (*Phase 2 study of everolimus monotherapy in patient with nonfunctioning neuroendocrine tumor or pheochromocytomas/paraglangliomas. Do-Young Oh et al. Cancer 2012 <str...

ea0016p414 | Neuroendocrinology | ECE2008

Autoimmune hypophysitis and isolated corticotrophin deficiency

Gentil Alfonso , Martin Tomas , Torres Alberto , Serrano Isabel , Morales Cristobal , Maraver Silvia , Martinez de Pinillos Guiillermo , Garcia-Quiros Juan Manuel , Sendon Angel

Introduction: Isolated ACTH failure is a rare disorder characterized by a secondary adrenal failure and a considerable deterioration of the general state. In adults the has been established related to cranial traumatism and to autoimmune hypophysitis (AH). It has been pointed out that the isolated failure of pituitary tropin in the context of a AH, could end with a global pituitary failure.Objective: Evaluation of the shortage of isolated ACTH as a way o...