Searchable abstracts of presentations at key conferences in endocrinology

ea0016me6 | (1) | ECE2008

Beyond the bone: sporadic and hereditary hyperparathyroidism

Toth Miklos

The past 15 years resulted in a great progress of our understanding regarding the genetic basis, pathogenesis, symptomatology, laboratory diagnosis and differential diagnosis of hypercalcemic disorders both of those occurring seemingly sporadically and of those developing in a familial setting. Since serum calcium measurement takes as part of the routine laboratory screening examinations the number of asymptomatic and also of familial cases of primary hyperparathyroidism are i...

ea0063p18 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Evaluating the applicability of urinary miR-483-5p as a non-invasive marker in adrenocortical cancer patients

Decmann Abel , Bancos Irina , Thomas Melinda A , Turai Peter , Perge Pal , Toth Miklos , Patocs Attila , Igaz Peter

Introduction: Minimally invasive blood-borne circulating microRNAs might be used for the preoperative differentiation of adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA). Circulating hsa-miR-483-5p is so far the best microRNA biomarker of ACC. To the best of our knowledge, there have been no studies concerning the potential applicability of urinary has-miR-483-5p as a non-invasive biomarker of ACC and its correlation with plasma hsa-miR-483...

ea0037oc9.1 | Adrenal 2 | ECE2015

Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

Igaz Ivan , Nyiro Gabor , Nagy Zoltan , Perge Pal , Toth Miklos , Racz Karoly , Igaz Peter , Patocs Attila

Objective: MicroRNAs are short non-protein coding RNA molecules involved in the regulation of numerous homeostatic processes via modulating gene expression. There are some data that the expression of microRNA might be modulated by hormones, but the interaction of hormones and circulating microRNAs of adrenocortical origin is mostly unknown.Methods: The expression of six selected circulating microRNAs (hsa-miR-27a, hsa-miR-125b-2, hsa-miR-200b, hsa-miR-21...

ea0037gp.04.05 | Steroids | ECE2015

Glucocorticoid receptor and HSD11B1 gene polymorphisms influence the therapy and therapy-associated morbidities in patients with Addison's disease

Molnar Agnes , Kovesdi Annamaria , Szucs Nikolette , Toth Miklos , Igaz Peter , Racz Karoly , Patocs Attila

Objective: Glucocorticoids exert their effects through the glucocorticoid receptor (GR). The local, cell-type specific glucocorticoid effect is modulated by the 11β-hydroxysteroid dehydrogenase enzymes (HSD11B) responsible for the interconversion of cortisone and cortisol. Individual sensitivity against glucocorticoids and activity of the HSD11B enzymes are at least partly determined by genetic factors.Aim: To test whether SNPs of GR and HSD11B1 gen...

ea0037ep67 | Adrenal cortex | ECE2015

Glucocorticoid receptor polymorphisms not affect the therapy efficiency in adult, Hungarian patients with 21-hydroxylase deficiency

Klara Koncz , Abigel Farkas , Marton Doleaschall , Nikolett Szucs , Miklos Toth , Peter Igaz , Karoly Racz , Attila Patocs

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder caused by 21-hydroxylase deficiency in 95% of all cases. Two main clinical subtypes: the classical (manifested after birth, or in early newborn period) and the late onset (LO) phenotype (manifested commonly during puberty). The lifelong glucocorticoid (GC) supplementation is essential in therapy of these patients. Response to GC therapy is individual and partly genetically determined....

ea0022h1.2 | Oral Communications Highlights 1 | ECE2010

Novel pathogenetic pathways of adrenocortical tumors revealed by meta-analysis of genomics data

Szabo Peter , Tamasi Viola , Andrasfalvy Marton , Patocs Attila , Toth Miklos , Falus Andras , Racz Karoly , Igaz Peter

Objective: Sporadic adrenocortical tumors are common, but their pathogenesis is poorly elucidated. Several mRNA profiling and comparative genome hybridization (CGH) studies have been performed on adrenocortical tumors to date. Meta-analysis of these results may be warranted due to the low number of tumor samples examined in several individual studies. Here, we present an integrative meta-analysis of gene expression microarray and CGH studies performed to date on sporadic adren...

ea0081p120 | Endocrine-Related Cancer | ECE2022

Novel panels of tissue microRNAs to diagnose adrenocortical malignancy based on artificial intelligence tools

Turai Peter , Herold Zoltan , Nyiro Gabor , Borka Katalin , Micsik Tamas , Toke Judit , Szucs Nikolette , Toth Miklos , Patocs Attila , Igaz Peter

Adrenocortical tumors are common, occuring in 5-7% of the population. Adrenocortical carcinoma (ACC) is rare (0.7-2/million/year) and it has a poor prognosis with a five-year survival of less than 30% in advanced stages. The histological differentiation of benign and malignant adrenocortical tumors is challenging.Objectives: To explore the diagnostic utility of multiple microRNAs in various combinations as markers of adrenocortical malignancy by using ar...

ea0041gp121 | Neuroendocrinology | ECE2016

Expression of dopamine (DA) D2 receptors (D2R) in corticotroph cells is responsible for the switch of hypothalamic regulation of ACTH secretion to DA in lactating rats

Nagy Gyorgy M. , Feher Palma , Bodnar Ibolya , Reid Luke , Toth Zsuzsanna E. , Vecsernyes Miklos , Toth Bela E.

: Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion switches to dopamine (DA) with a parallel loss of DAerg control of alpha-melanocyte-stimulating hormone (α-MSH) release in lactating dams. It has been also shown that dephosphorylation/inactivation of tyrosine hydroxylase (TH) in terminals of DA neurons at the median eminence is required not only for suckling-induced PRL release but also for ACTH responses. The aim of the present study was...

ea0022p32 | Adrenal | ECE2010

Utility of midnight salivary cortisol measurement in the diagnosis of overt and subclinical Cushing's syndrome

Sereg Marta , Toke Judit , Patocs Attila , Igaz Peter , Szucs Nikolett , Varga Ibolya , Szappanos Agnes , Glaz Edit , Racz Karoly , Toth Miklos

Background: Midnight salivary cortisol (SalC2400) measurement has been recently suggested as one of the first-line screening tests for hypercortisolism.Aims: In our present study, we evaluated the clinical utility of the salivary cortisol (SalC) measurement in the diagnosis of both overt and subclinical Cushing’s syndrome.Patients and methods: Patients with overt Cushing’s syndrome (n=23, group A) and those with su...

ea0016p676 | Steroid receptors | ECE2008

Glucocorticoid receptor gene polymorphisms in patients with Cushing's disease and adrenal Cushing's syndrome

Szappanos Agnes , Patocs Attila , Toke Judit , Sereg Marta , Futo Laszlo , Kende Zoltan , Varga Ibolya , Glaz Edit , Racz Karoly , Toth Miklos

Introduction: The hypothalamic–pituitary–adrenal axis setpoint and the glucocorticoid sensitivity in various tissues are at least partly genetically determined. The glucocorticoid receptor (GR) gene polymorphisms may have an impact on the development and/or the variability of clinical manifestations of endogenous hypercortisolism, however their role has not been investigated in patients with endogenous hypercortisolism.Methods: We investigated ...