Endocrine Abstracts

The renin–angiotensin system is known to enhance erythropoiesis. (Pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, has recently been identified. We have recently shown expression of (P)RR in a human erythroid cell line, YN-1. It is known that triiodothyronine (T3) and angiotensin-II (A-II) stimulate proliferation of erythroid cells. The aim of the present study is to clarify effects of T3 and A-II on expression of (P)RR in the ...

Kisspeptins are the product of the KiSS-1 gene, a metastasis suppressor gene, and play important physiological roles in the hypothalamo-pituitary gonadal axis and reproduction. It was reported that kisspeptin-10 stimulated the aldosterone synthesis in H295R human adrenal cancer cells (Nakamura et al., 2007). However, expression of kisspeptin and its receptor has not been studied in tumor tissues of adrenocortical tumors. The aim of the present study was therefore to clarify ex...