Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc10.6 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Opposite actions of LEAP-2 and ghrelin in energy homeostasis

Masa Sabela Casado , De Oliveira Diz Tadeu , Miguens Marta Varela , Gonzalez Carlos Dieguez , Carro Sulay Tovar

Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently characterized as an endogenous GHSR1a antagonist. LEAP-2 is produced mainly in the liver, and it was described that an acute ghrelin administration blocks food intake, GH release and normalize glucose levels during chronic caloric restriction. For this reason, it could be considered as a key endocrine factor in the regulation of systemic energy metabolism. Nevertheless, the exact mechanism of action is still un...

ea0014p120 | (1) | ECE2007

Ret expression reduces estrogen-induced lactotrope hyperplasia

Cañibano Carmen , Rodríguez Noela , Tovar Sulay , Vázquez María Jesús , Lavandeira Montserrat , Díeguez Carlos , Álvarez Clara

RET is a tyrosine kinase receptor activated by GDNF, NTN, ART and PSPN through GFRa1,2, 3 and 4 respectively. Activation of the receptor elicits intracellular pathways such us Ras/MAPK and PI3K/AKT leading to differentiation and proliferation. Our group has previously shown that RET is expressed specifically in the somatotroph cell population within the pituitary gland, both in rats and in humans. We have also shown that, in absence of its ligand GDNF, RET induces activation o...

ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

p63 induces the fibrosis in NASH

Fondevila Marcos F , Novoa Eva , Uxía Fernández , María J González-Rellán , Lima Natalia , Begoña Porteiro , Juan Cuñarro , Tovar Sulay , Fidalgo Miguel , Martinez-Chantar Maria Luz , Sabio Guadalupe , Marcos Miguel , Lopez Miguel , Dieguez Carlos , Rubén Nogueiras

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...